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Non-Coding RNA, Volume 7, Issue 1
March 2021 - 23 articles
Cover Story: In silico predictions and interactions must be considered pivotal starting points to screen and design novel drugs to counter SARS-CoV-2-induced inflammatory complications. Indeed, we identified selective motifs in the leader sequence of the SARS-CoV-2 genome as promising sites to generate antiviral selective drugs. Notably, major effective mutations currently reported for SARS-CoV-2 variants involve coding regions, whereas reliable mutations in the leader sequence and correlations with the severity of COVID-19 disease are missing. We identified target motifs in the leader sequence suitable for specific bindings with endogenous human miRNAs and lncRNAs that can be therefore considered a conceptual background for the development of RNA-based drugs against COVID-19. View this paper.
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Non-Coding RNA - ISSN 2311-553X