Non-Coding RNA, Volume 6, Issue 1
2020 March - 14 articles
Cover Story: StrRNAs are specific RNAs containing short tandem repeat-enriched sequences that play an architectural role in the formation of membraneless nuclear bodies by association with multiple copies of specific RNA-binding proteins (RBPs) (left). Specific nuclear bodies are formed by the induced expression of strRNAs in response to cellular stress or disease-related repeat expansion. The functional models of strRNA-dependent nuclear bodies (right). Top: Molecular sponge of specific proteins and/or RNAs from the nucleoplasm to negatively regulate their functions. Middle: Reaction crucible where specific molecules, such as enzymes and their substrates, are concentrated to facilitate their catalytic reaction. Bottom: Disease-associated aggregation is formed on disease-causing or toxic strRNAs transcribed from the abnormally expanded repeat sequences. View this paper.
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Non-Coding RNA - ISSN 2311-553X