Non-Coding RNA, Volume 12, Issue 4
2026 August - 11 articles
Cover Story: Circular RNAs (circRNAs) are abundant, stable non-coding transcripts enriched in the nervous system, showing compartmentalized localization within dendrites, axons and synapses. In this review, we examine how circRNAs reach these sites, focusing on RNP complexes exploiting kinesin/dynein cytoskeletal transport. Using circHomer1, CDR1as and circDlc1(2) as paradigms, we discuss how circRNA trafficking shapes synaptic gene expression via microRNA interaction and RNA-binding protein (RBP) scaffolding, while circPcmtd1 is locally translated into a functional micropeptide. We further show how disease-linked RBPs such as FUS disrupt circRNA transport in ALS, trapping transcripts within pathological aggregates. Altogether, we position circRNAs as dynamically and spatially regulated components of neuronal RNA biology relevant to synaptic function. View this paper
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Non-Coding RNA - ISSN 2311-553X