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Gels, Volume 11, Issue 12

December 2025 - 86 articles

Cover Story: Gelatin-based hydrogels are promising for pharmaceutical and biomedical applications. However, their thermo-sensitivity often restricts practical use. Low-molecular-weight gelatin (LMWG) was obtained through controlled degradation of gelatin with hydroxylamine, and hydrogels were prepared by crosslinking with genipin. LMWG exhibited superior processability, remaining liquid at room temperature, and LMWG-genipin hydrogels showed higher swelling capacity, increased porosity, and improved flexibility without loss of mechanical integrity. Rheological analysis confirmed differences in thermo-sensitivity, and cytocompatibility assays demonstrated low toxicity and proliferation of cells on the materials. The combination of molecular weight modulation and crosslinking by genipin provides an effective strategy to develop gelatin-based hydrogels. View this paper
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Articles (86)

  • Article
  • Open Access
303 Views
22 Pages

Impact of CeO2-Doped Bioactive Glass on the Properties of CMC/PEG Hydrogels Intended for Wound Treatment

  • Sofia Pacheco,
  • Inês Alexandra Marques,
  • Ana Salomé Pires,
  • Maria Filomena Botelho,
  • Sílvia Soreto Teixeira,
  • Manuel Graça and
  • Sílvia Gavinho

16 December 2025

Diabetes mellitus is a serious public health problem, mainly due to the difficulty in healing chronic wounds, which present an inflammatory response for long periods of time and are more vulnerable to infections. Hydrogels are a promising therapeutic...

  • Article
  • Open Access
423 Views
19 Pages

16 December 2025

Tea polyphenols (TP) offer health benefits, but their stability is compromised by sensitivity to environmental factors, limiting their applications. Developing stimulus-responsive delivery systems that precisely control TP release is essential. This...

  • Article
  • Open Access
325 Views
17 Pages

13 December 2025

The paper analyses the effect of the solvent amount and nature on the structure and mechanical properties of hydrogels based on copolymers of 2-hydroxyethylmethacrylate (HEMA) with polyvinylpyrrolidone (PVP). The synthesis of pHEMA-gr-PVP copolymers...

  • Article
  • Open Access
265 Views
12 Pages

H2O2-Assisted Fabrication of Stiff and Tough Hydrogel Using Natural Cysteine-Rich Protein

  • Mengting Fan,
  • Beizhe Huang,
  • Yuhan Li,
  • Ting Zhang,
  • Ranjith Kumar Kankala and
  • Jianting Zhang

13 December 2025

Protein-based hydrogels have emerged as an important class of materials for biomedical applications. However, these hydrogels often exhibit inferior mechanical properties, significantly limiting their potential applicability. Herein, a simplified yet...

  • Review
  • Open Access
1 Citations
585 Views
22 Pages

Comparative Evaluation of Spreadability Measurement Methods for Topical Semisolid Formulations/A Scoping Review

  • Elham Y. Al-Barghouthy,
  • Saja Hamed,
  • Ghadeer F. Mehyar and
  • Hatim S. AlKhatib

12 December 2025

Background: Spreadability is a critical performance attribute for semisolid formulations, influencing patient compliance, dose uniformity, and product acceptability. Despite its importance, there is no standardized method for its assessment across ph...

  • Article
  • Open Access
294 Views
18 Pages

Eco-Friendly Hydrogels from Natural Gums and Cellulose Citrate: Formulations and Properties

  • Giuseppina Anna Corrente,
  • Fabian Ernesto Arias Arias,
  • Eugenia Giorno,
  • Paolino Caputo,
  • Nicolas Godbert,
  • Cesare Oliviero Rossi,
  • Iolinda Aiello,
  • Candida Milone and
  • Amerigo Beneduci

12 December 2025

The design of sustainable hydrogel materials with tunable mechanical and thermal properties is essential for emerging applications in flexible and wearable electronics. In this study, hydrogels based on natural gums such as Guar, Tara, and Xanthan an...

  • Article
  • Open Access
240 Views
21 Pages

Effect of Ultrasonic Treatment of Dispersed Carbon Nanocomposite Media on the Formation, Electrical Conductivity, and Degradation of a Hydrogel for Metallic Stimulation Electrodes

  • Mikhail Savelyev,
  • Artem Kuksin,
  • Denis Murashko,
  • Ekaterina Otsupko,
  • Victoria Suchkova,
  • Kristina Efremova,
  • Pavel Vasilevsky,
  • Ulyana Kurilova,
  • Sergey Selishchev and
  • Alexander Gerasimenko

12 December 2025

This study investigates the impact of ultrasonic treatment on the deagglomeration of aggregates of single-walled carbon nanotubes (SWCNTs) and reduced graphene oxide (rGO). The aim of the research is to enhance the electrical conductivity of a biopol...

  • Article
  • Open Access
268 Views
26 Pages

12 December 2025

This study investigated the influence of coconut oil concentration (0–2%) on the nonlinear rheological and thermal behavior of soy protein concentrate (SPC) mixtures and integrated these data into computational fluid dynamics (CFD) models to pr...

  • Article
  • Open Access
401 Views
33 Pages

11 December 2025

LACMA’s 19th-century Tibetan Altar Table with Auspicious Symbols is characterized by a complex stratigraphy comprising animal glue-based ground and paint layers, a presumably original tung oil-based varnish, and a dark surface layer composed of...

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Gels - ISSN 2310-2861