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Journal of Fungi, Volume 7, Issue 4
2021 April - 79 articles
Cover Story: Although melanins are among the great pigments of nature, their structure is still unknown. Fungal melanins are a potent defense against diverse host effector immune responses, and they reduce the efficacy of certain antifungals. Cryptococcus neoformans forms melanin only in the presence of exogenous phenolic substrates, which facilitates the study of this enigmatic polymer. Melanin “ghosts” of fungal cells, such as those derived from C. neoformans, reveal structural details and provide a platform for diverse deep analyses, such as by atomic force microscopy and mass spectrometry. View this paper
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