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Journal of Cardiovascular Development and Disease, Volume 12, Issue 7

July 2025 - 43 articles

Cover Story: The anatomy of the atrioventricular node has been likened to a riddle wrapped up in an enigma. New data are required if, as did Oedipus, it proves possible to solve the riddle of the Sphinx. The possibility of providing such information is now enhanced by the ability to demonstrate the recognised landmarks to the node using clinical computed tomography. These reconstructions reveal that the well-recognised triangle of Koch is the right atrial surface of a pyramid, with its walls enclosing the inferior pyramidal space. We show how it is now possible to relate the histological and anatomical features of the contents of the pyramid including the node itself. We anticipate that such anatomical information will enhance the ability for electrophysiologists to locate directly the node and its atrial inputs. View this paper
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Articles (43)

  • Review
  • Open Access
1,014 Views
19 Pages

Indirect Myocardial Injury in Polytrauma: Mechanistic Pathways and the Clinical Utility of Immunological Markers

  • Makhabbat Bekbossynova,
  • Timur Saliev,
  • Murat Mukarov,
  • Madina Sugralimova,
  • Arman Batpen,
  • Anar Kozhakhmetova and
  • Aknur Zhanbolat

Myocardial injury following polytrauma is a significant yet often underdiagnosed condition that contributes to acute cardiac dysfunction and long-term cardiovascular complications. This review examines the role of systemic inflammation, oxidative str...

  • Systematic Review
  • Open Access
1,591 Views
13 Pages

Activated Clotting Time and Haemostatic Complications in Patients Receiving ECMO Support: A Systematic Review

  • Daniel Schwaiger,
  • Lukas Schausberger,
  • Benedikt Treml,
  • Dragana Jadzic,
  • Nicole Innerhofer,
  • Christoph Oberleitner,
  • Zoran Bukumirić,
  • Igor Spurnić and
  • Sasa Rajsic

Background: Extracorporeal membrane oxygenation (ECMO) requires systemic anticoagulation to prevent clotting, typically using unfractionated heparin (UFH). However, anticoagulation carries a bleeding risk, necessitating monitoring. Activated clotting...

  • Review
  • Open Access
1 Citations
2,988 Views
20 Pages

MAPK, PI3K/Akt Pathways, and GSK-3β Activity in Severe Acute Heart Failure in Intensive Care Patients: An Updated Review

  • Massimo Meco,
  • Enrico Giustiniano,
  • Fulvio Nisi,
  • Pierluigi Zulli and
  • Emiliano Agosteo

Acute heart failure (AHF) is a clinical syndrome characterized by the sudden onset or rapid worsening of heart failure signs and symptoms, frequently triggered by myocardial ischemia, pressure overload, or cardiotoxic injury. A central component of i...

  • Review
  • Open Access
3,673 Views
19 Pages

Cardiac Rehabilitation After Mitral Valve Intervention: Tailored Assessment, Management, and Exercise Training

  • Francesco Perone,
  • Monica Loguercio,
  • Federica Sabato,
  • Annalisa Pasquini,
  • Marina Ostojic,
  • Ashot Avagimyan,
  • Vaida Sileikiene,
  • Joanna Popiolek-Kalisz,
  • Aneta Aleksova and
  • Marco Ambrosetti

Cardiac rehabilitation should be suggested after mitral valve intervention. Physical exercise is associated with improved cardiorespiratory fitness and clinical outcome and reduced rehospitalization and mortality in patients after heart valve surgery...

  • Article
  • Open Access
1,464 Views
15 Pages

(1) Background: Our aim was to evaluate the diagnostic performance of combined coronary computed tomography angiography (CCTA) and dynamic CT myocardial perfusion imaging (CT-MPI) for detecting hemodynamically significant coronary artery disease (CAD...

  • Systematic Review
  • Open Access
2 Citations
1,587 Views
13 Pages

Surgical vs. Medical Management of Infective Endocarditis Following TAVR: A Systematic Review and Meta-Analysis

  • Dimitrios E. Magouliotis,
  • Serge Sicouri,
  • Massimo Baudo,
  • Francesco Cabrucci,
  • Yoshiyuki Yamashita and
  • Basel Ramlawi

Background: Infective endocarditis after transcatheter aortic valve replacement (TAVR-IE) is a rare but severe complication associated with high morbidity and mortality. The optimal treatment strategy—surgical explantation versus medical therap...

  • Case Report
  • Open Access
1 Citations
2,147 Views
6 Pages

Aorto-esophageal fistula (AEF) is a condition with an extremely high mortality rate that often causes massive gastrointestinal bleeding, commonly resulting from esophageal perforation due to foreign bodies or aortic aneurysmal malformations. This cas...

  • Article
  • Open Access
2 Citations
1,135 Views
16 Pages

The Prognostic Implication of Left Atrial Strain Parameters with Conventional Left Atrial Parameters for the Prediction of Adverse Outcomes in Asian Patients with Hypertrophic Cardiomyopathy—An Echocardiographic Study

  • Andre Seah,
  • Tony Y. W. Li,
  • Novi Yanti Sari,
  • Chi-Hang Lee,
  • Tiong-Cheng Yeo,
  • James W. L. Yip,
  • Yoke Ching Lim,
  • Kian-Keong Poh,
  • William K. F. Kong and
  • Weiqin Lin
  • + 2 authors

Background/Objectives: Left atrial function can be a tool for risk stratification for hypertrophic cardiomyopathy (HCM). Over the past decade, there has been growing interest in the application of strain analysis for earlier and more accurate predict...

  • Review
  • Open Access
1 Citations
2,190 Views
14 Pages

Divergent Cardiac Adaptations in Endurance Sport: Atrial Fibrillation Markers in Marathon Versus Ultramarathon Athletes

  • Zbigniew Waśkiewicz,
  • Eduard Bezuglov,
  • Oleg Talibov,
  • Robert Gajda,
  • Zhassyn Mukhambetov,
  • Daulet Azerbaev and
  • Sergei Bondarev

Endurance training induces significant cardiac remodeling, with evidence suggesting that prolonged high-intensity exercise may increase the risk of atrial fibrillation (AF). However, physiological responses differ by event type. This review compares...

  • Article
  • Open Access
2 Citations
2,622 Views
14 Pages

Stroke Risk Stratification in Incident Atrial Fibrillation: A Sex-Specific Evaluation of CHA2DS2-VA and CHA2DS2-VASc

  • Jose L. Clua-Espuny,
  • Anna Panisello-Tafalla,
  • Jorgina Lucas-Noll,
  • Eulàlia Muria-Subirats,
  • Teresa Forcadell-Arenas,
  • Juan M. Carrera-Ortiz,
  • Pedro Molto-Balado,
  • Josep Clua-Queralt,
  • Immaculada Fusté-Anguera and
  • Silvia Reverte-Vilarroya

(1) Background: In the absence of locally validated tools, the CHA2DS2-VA score has been suggested as a substitute for the CHA2DS2-VASc score. This study compared the potential discrepancies between these scores. (2) Methods: The observational, retro...

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J. Cardiovasc. Dev. Dis. - ISSN 2308-3425