Veterinary Sciences, Volume 11, Issue 12
2024 December - 92 articles
Cover Story: Pigeon paramyxovirus type 1 (PPMV-1), a variant of chicken-origin Newcastle disease virus (NDV), causes pigeon Newcastle disease (ND). In this study, we investigate the impact of two key amino acid mutations, G347E and E349D, in the PPMV-1 hemagglutinin–neuraminidase (HN) protein on viral host tropism, replication, and pathogenicity. The mutations reduced viral replication and neuraminidase activity in pigeon cells but enhanced these properties in chicken cells. Additionally, the mutations shifted the receptor binding preference from α-2,6 to α-2,3 sialic acid. In vivo, the mutations decreased pathogenicity and transmission in pigeons but increased virulence and transmissibility in chickens, highlighting their role in modulating host adaptation and interspecies transmission. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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