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Bioengineering, Volume 8, Issue 8

August 2021 - 16 articles

Cover Story: A new class of porous 3D dual network composite hydrogel scaffolds with osteogenic ions: Ca2+, Zn2+, and Sr2+ was developed by sequential formation of the networks with differences in the ion-alginate affinity, accounting for the differences in properties. These composites resembled the morphology of trabecular bone with high interconnectivity and isotropy, allowing cells to thrive and to evenly dissipate energy from multidirectional loads. The simple fabrication process and low costs of these scaffolds with osteoinductive properties thus have translational potential to replace autografting in bone defects, especially for oral and maxillofacial surgery. View this paper.
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Articles (16)

  • Article
  • Open Access
7 Citations
3,514 Views
18 Pages

Modulation of Synthetic Tracheal Grafts with Extracellular Matrix Coatings

  • Lumei Liu,
  • Sayali Dharmadhikari,
  • Robert A. Pouliot,
  • Michael M. Li,
  • Peter M. Minneci,
  • Zhenghong Tan,
  • Kimberly Shontz,
  • Jed Johnson,
  • Susan D. Reynolds and
  • Christopher K. Breuer
  • + 2 authors

Synthetic scaffolds for the repair of long-segment tracheal defects are hindered by insufficient biocompatibility and poor graft epithelialization. In this study, we determined if extracellular matrix (ECM) coatings improved the biocompatibility and...

  • Feature Paper
  • Review
  • Open Access
143 Citations
13,941 Views
19 Pages

Biosurfactants: Properties and Applications in Drug Delivery, Biotechnology and Ecotoxicology

  • Thiago R. Bjerk,
  • Patricia Severino,
  • Sona Jain,
  • Conrado Marques,
  • Amélia M. Silva,
  • Tatiana Pashirova and
  • Eliana B. Souto

Surfactants are amphiphilic compounds having hydrophilic and hydrophobic moieties in their structure. They can be of synthetic or of microbial origin, obtained respectively from chemical synthesis or from microorganisms’ activity. A new generation of...

  • Article
  • Open Access
1 Citations
4,141 Views
18 Pages

We previously developed the biochemical reaction simulator WinBEST-KIT. In recent years, research interest has shifted from analysis of individual biochemical reactions to analysis of metabolic pathways as systems. These large-scale and complicated m...

  • Review
  • Open Access
60 Citations
12,018 Views
31 Pages

Drug and chemical development along with safety tests rely on the use of numerous clinical models. This is a lengthy process where animal testing is used as a standard for pre-clinical trials. However, these models often fail to represent human physi...

  • Review
  • Open Access
9 Citations
5,411 Views
15 Pages

How Do Mechanics Guide Fibroblast Activity? Complex Disruptions during Emphysema Shape Cellular Responses and Limit Research

  • Mathew N. Leslie,
  • Joshua Chou,
  • Paul M. Young,
  • Daniela Traini,
  • Peta Bradbury and
  • Hui Xin Ong

The emphysema death toll has steadily risen over recent decades, causing the disease to become the third most common cause of death worldwide in 2019. Emphysema is currently incurable and could be due to a genetic condition (Alpha-1 antitrypsin defic...

  • Article
  • Open Access
3 Citations
3,209 Views
22 Pages

Walking support systems are essential for blind people. In this study, the presentation of phosphene position is focused on as a method to detect obstacles for blind people. When the phosphene is used in a walking support system, it is necessary to a...

  • Article
  • Open Access
2 Citations
4,874 Views
16 Pages

Self-Organogenesis from 2D Micropatterns to 3D Biomimetic Biliary Trees

  • Emilie Gontran,
  • Lorena Loarca,
  • Cyrille El Kassis,
  • Latifa Bouzhir,
  • Dmitry Ayollo,
  • Elsa Mazari-Arrighi,
  • Alexandra Fuchs and
  • Pascale Dupuis-Williams

Background and Aims: Globally, liver diseases account for 2 million deaths per year. For those with advanced liver disease the only curative approach is liver transplantation. However, less than 10% of those in need get a liver transplant due to limi...

  • Review
  • Open Access
27 Citations
5,743 Views
14 Pages

Combined Strategies to Prompt the Biological Reduction of Chlorinated Aliphatic Hydrocarbons: New Sustainable Options for Bioremediation Application

  • Marta M. Rossi,
  • Edoardo Dell’Armi,
  • Laura Lorini,
  • Neda Amanat,
  • Marco Zeppilli,
  • Marianna Villano and
  • Marco Petrangeli Papini

Groundwater remediation is one of the main objectives to minimize environmental impacts and health risks. Chlorinated aliphatic hydrocarbons contamination is prevalent and presents particularly challenging scenarios to manage with a single strategy....

  • Article
  • Open Access
5 Citations
4,535 Views
22 Pages

Despite considerable advances in biomaterials-based bone tissue engineering technologies, autografts remain the gold standard for rehabilitating critical-sized bone defects in the oral and maxillofacial (OMF) region. A majority of advanced synthetic...

  • Review
  • Open Access
25 Citations
6,276 Views
29 Pages

Stem Cell Niche Microenvironment: Review

  • Mohamed Abdul-Al,
  • George Kumi Kyeremeh,
  • Morvarid Saeinasab,
  • Saeed Heidari Keshel and
  • Farshid Sefat

The cornea comprises a pool of self-regenerating epithelial cells that are crucial to preserving clarity and visibility. Limbal epithelial stem cells (LESCs), which live in a specialized stem cell niche (SCN), are crucial for the survival of the huma...

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Bioengineering - ISSN 2306-5354