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Toxics, Volume 8, Issue 1

March 2020 - 20 articles

Cover Story: Toxic environmental chemicals can cause functional perturbation of the human gut microbiome, thereby potentially leading to human diseases. The establishment of gut microbiome toxicity links the toxic effects of various environmental agents with microbiota-associated diseases, calling for more comprehensive toxicity assessment. View this paper.
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Articles (20)

  • Review
  • Open Access
102 Citations
17,921 Views
18 Pages

Gut Microbiome Toxicity: Connecting the Environment and Gut Microbiome-Associated Diseases

  • Pengcheng Tu,
  • Liang Chi,
  • Wanda Bodnar,
  • Zhenfa Zhang,
  • Bei Gao,
  • Xiaoming Bian,
  • Jill Stewart,
  • Rebecca Fry and
  • Kun Lu

12 March 2020

The human gut microbiome can be easily disturbed upon exposure to a range of toxic environmental agents. Environmentally induced perturbation in the gut microbiome is strongly associated with human disease risk. Functional gut microbiome alterations...

  • Article
  • Open Access
27 Citations
5,861 Views
15 Pages

Concentration- and Time-Dependent Effects of Benzalkonium Chloride in Human Lung Epithelial Cells: Necrosis, Apoptosis, or Epithelial Mesenchymal Transition

  • Sou Hyun Kim,
  • Doyoung Kwon,
  • Seunghyun Lee,
  • Seung Won Son,
  • Jung-Taek Kwon,
  • Pil-Je Kim,
  • Yun-Hee Lee and
  • Young-Suk Jung

2 March 2020

Benzalkonium chloride (BAC), an antimicrobial agent in inhalable medications and household sprays, has been reported to be toxic to pulmonary organs. Although cell membrane damage has been considered as the main cytotoxic mechanism of BAC, its concen...

  • Article
  • Open Access
35 Citations
5,668 Views
14 Pages

A Comparison of the Nephrotoxicity of Low Doses of Cadmium and Lead

  • Soisungwan Satarug,
  • Glenda C. Gobe,
  • Pailin Ujjin and
  • David A. Vesey

2 March 2020

Environmental exposure to moderate-to-high levels of cadmium (Cd) and lead (Pb) is associated with nephrotoxicity. In comparison, the health impacts of chronic low-level exposure to Cd and Pb remain controversial. The aim of this study was to therefo...

  • Communication
  • Open Access
13 Citations
4,409 Views
8 Pages

1 March 2020

In the fish embryo toxicity (FET) test with zebrafish (Danio rerio) embryos, 3,4-dichloroaniline (3,4-DCA) is often employed as a positive control substance. Previous studies have characterized bioconcentration and transformation of 3,4-DCA in this t...

  • Communication
  • Open Access
29 Citations
5,546 Views
10 Pages

22 February 2020

Mercury (Hg) contamination in soil and forage plants is toxic to ecosystems, and artisanal and small-scale gold mining (ASGM) is the main source of such pollution in the Bombana area of Indonesia. Hg contamination in soil and forage plants was invest...

  • Communication
  • Open Access
31 Citations
4,901 Views
8 Pages

15 February 2020

Microplastics (MPs) are emerging pollutants, which are considered ubiquitous in aquatic ecosystems. The effects of MPs on aquatic biota are still poorly understood, and consequently, there is a need to understand the impacts that MPs may pose to orga...

  • Article
  • Open Access
12 Citations
3,579 Views
10 Pages

Biomonitoring of Trace Elements in Subjects Living Near a Hazardous Waste Incinerator: Concentrations in Autopsy Tissues

  • Francisco García,
  • Montse Marquès,
  • Eneko Barbería,
  • Pilar Torralba,
  • Inés Landin,
  • Carlos Laguna,
  • José L. Domingo and
  • Martí Nadal

11 February 2020

The only hazardous waste incinerator (HWI) in Spain started to operate in 1999. Twenty years later, the levels of 11 trace elements (As, Be, Cd, Cr, Hg, Mn, Ni, Pb, Sn, Tl and V) were analyzed in five different autopsy tissues (kidney, liver, brain,...

  • Article
  • Open Access
11 Citations
3,894 Views
15 Pages

Potential of Inactivated Bifidobacterium Strain in Attenuating Benzo(A)Pyrene Exposure-Induced Damage in Colon Epithelial Cells In Vitro

  • Mengfan Xu,
  • Lili Fu,
  • Junwen Zhang,
  • Tao Wang,
  • Junfeng Fan,
  • Baoqing Zhu,
  • Piotr Dziugan,
  • Bolin Zhang and
  • Hongfei Zhao

11 February 2020

Long-term exposure to benzo(a)pyrene (BaP) poses a serious genotoxic threat to human beings. This in vitro study investigated the potential of inactivated Bifidobacterium animalis subsp. lactis BI-04 in alleviating the damage caused by BaP in colon e...

  • Article
  • Open Access
16 Citations
4,220 Views
20 Pages

11 February 2020

In order to assess the environmental risk of a pharmaceutical, information is needed on the sorption of the compound to solids. Here we use a high-quality database of measured sorption coefficients, all determined following internationally recognised...

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Toxics - ISSN 2305-6304