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Antioxidant Characterization and Biological Effects of Grape Pomace Extracts Supplementation in Caenorhabditis elegans

1
Grupo de Investigación en Polifenoles, Universidad de Salamanca, Campus Miguel de Unamuno, 37007 Salamanca, Spain
2
Institute of Food Science Research (CIAL), CSIC-UAM, C/ Nicolás Cabrera 9, 28049 Madrid, Spain
3
Bodega Matarromera, S.L. Ctra. San Bernardo s/n. Valbuena de Duero, 47359 Valladolid, Spain
*
Author to whom correspondence should be addressed.
Foods 2019, 8(2), 75; https://doi.org/10.3390/foods8020075
Received: 18 January 2019 / Revised: 11 February 2019 / Accepted: 12 February 2019 / Published: 15 February 2019
(This article belongs to the Special Issue Analysis and Health Benefits of Wine Polyphenols)
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Abstract

The aim of this work was to evaluate the biological activity of four grape pomace (GP) extracts that are rich in polyphenols using C. elegans as an in vivo model. Different concentrations of the GP extracts were assessed for their effects on the resistance of C. elegans against thermally induced oxidative stress, accumulation of reactive oxygen species (ROS), and lifespan. The cultivation of C. elegans with relatively low concentrations of GP extracts increased their resistance against thermal stress and prolonged their lifespan, while high levels displayed detrimental effects. In the studied extracts, maximum protection was observed for levels of polyphenols around 7 to 9 µg gallic acid equivalents per cultivation plate. The obtained results suggested that small changes in the ROS levels could have beneficial effects, although further studies are required to fully understand the impact of the extracts and assayed doses on ROS levels to explain the mechanism that is involved in the observed effects. View Full-Text
Keywords: grape pomace; C. elegans; oxidative stress; ROS; lifespan; antioxidant activity grape pomace; C. elegans; oxidative stress; ROS; lifespan; antioxidant activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Ayuda-Durán, B.; González-Manzano, S.; Gil-Sánchez, I.; Moreno-Arribas, M.V.; Bartolomé, B.; Sanz-Buenhombre, M.; Guadarrama, A.; Santos-Buelga, C.; González-Paramás, A.M. Antioxidant Characterization and Biological Effects of Grape Pomace Extracts Supplementation in Caenorhabditis elegans. Foods 2019, 8, 75.

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