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Separations, Volume 10, Issue 1

January 2023 - 62 articles

Cover Story: Ischemic stroke is the first cause of disability and second cause of death around the world. Thrombolysis with intravenous rt-PA is the most commonly administered fibrinolytic medical therapy. The use of different HPLC methodologies evaluating plasma samples from 108 patients treated and non-treated with rt-PA has allowed us to find that a group of highly hydrophilic compounds, with a molecular mass of 821 Da (determined by ESI-MS), were present in plasma samples of 80% of the treated patients soon after receiving treatment as the result of the rt-PA thrombolytic effect. A significant association was found between the presence of these compounds and the good neurological evolution of patients as 70% of patients yielding these compounds had early neurological improvement. View this paper
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Articles (62)

  • Review
  • Open Access
15 Citations
4,903 Views
20 Pages

Hydrophilic interaction liquid chromatography (HILIC) today is a well-known and largely applied technique to analyse polar compounds such as pharmaceuticals, metabolites, proteins, peptides, amino acids, oligonucleotides, and carbohydrates. Due to th...

  • Article
  • Open Access
67 Citations
10,695 Views
18 Pages

Evaluation of Antimicrobial Activity and Cytotoxicity Effects of Extracts of Piper nigrum L. and Piperine

  • Fabrine Silva Alves,
  • Jorddy Neves Cruz,
  • Ingryd Nayara de Farias Ramos,
  • Dayse Lucia do Nascimento Brandão,
  • Rafael Nascimento Queiroz,
  • Glauce Vasconcelos da Silva,
  • Gleice Vasconcelos da Silva,
  • Maria Fani Dolabela,
  • Marcondes Lima da Costa and
  • André Salim Khayat
  • + 2 authors

P. nigrum L. extracts and the piperine alkaloid have important antimicrobial, anti-inflammatory, and antioxidant properties. Therefore, in this study, we evaluated the antimicrobial activity and cytotoxicity of P. nigrum L. extracts and piperine, a c...

  • Review
  • Open Access
13 Citations
5,152 Views
22 Pages

Membrane filtration technology has attracted extensive attention in academia and industry due to its advantages of eco-friendliness related to environmental protection and high efficiency. Polyamide thin-film composite nanofiltration (PA TFC NF) memb...

  • Article
  • Open Access
4 Citations
2,581 Views
19 Pages

Phenomena of Bacillus sphaericus LMG 22257 Activity and Its Influence on Properties of Portland Cement Mortar Exposed to Different Curing Media

  • Siti Baizura Mahat,
  • Megat Azmi Megat Johari,
  • Norfaniza Mokhtar,
  • Choong Kok Keong,
  • Mohd Nazri Idris,
  • Wan Zafira Ezza Wan Zakaria,
  • Charles Ng WaiWai Chun and
  • Husnul Azan Tajarudin

This study determined the influences of Bacillus sphaericus Laboratorium voor Microbiologie Gent (LMG) 22257 bacteria activity on mortar samples cured in various media regarding compressive strength, porosity, water absorption, and water permeab...

  • Article
  • Open Access
24 Citations
7,708 Views
19 Pages

A Comparative Study of Chamomile Essential Oils and Lipophilic Extracts Obtained by Conventional and Greener Extraction Techniques: Chemometric Approach to Chemical Composition and Biological Activity

  • Gökhan Zengin,
  • Adriano Mollica,
  • Jelena Arsenijević,
  • Branimir Pavlić,
  • Zoran Zeković,
  • Kouadio Ibrahime Sinan,
  • Linlin Yan,
  • Aleksandra Cvetanović Kljakić and
  • Slavica Ražić

Bearing in mind the centuries-old traditional use of chamomile, but also the increasing demand for its products in modern industry, oriented toward sustainable development, there are increasing efforts for the efficient extraction of high-value compo...

  • Review
  • Open Access
20 Citations
6,002 Views
19 Pages

Research Progress on Adsorption and Separation of Petroleum Hydrocarbon Molecules by Porous Materials

  • Haibin Yu,
  • Jiazhong Zang,
  • Chunlei Guo,
  • Bin Li,
  • Ben Li,
  • Xueyin Zhang and
  • Tiehong Chen

Petroleum is an indispensable chemical product in industrial production and daily life. The hydrocarbon molecules in petroleum are important raw materials in the organic chemical industry. The hydrocarbons currently used in industry are usually obtai...

  • Article
  • Open Access
7 Citations
3,351 Views
20 Pages

Apigenin (API) has many biological activities, but its poor solubility limits its clinical application. In this research, API nanoparticles were prepared by the liquid antisolvent precipitation (LAP) technique, which effectively improved the solubili...

  • Article
  • Open Access
8 Citations
2,554 Views
9 Pages

Study of Efficiency of Capacity Gradient Ion-Exchange Stationary Phases

  • Szabolcs Horváth,
  • Diána Lukács,
  • Evelin Farsang and
  • Krisztián Horváth

Highly efficient columns are necessary for the modern analytical applications of liquid chromatography. In this work, the separation efficiency of ion-exchange capacity gradient stationary phases combined with eluent concentration gradient was studie...

  • Article
  • Open Access
6 Citations
5,697 Views
9 Pages

Product safety is important for medicines. For drugs on the market, it must be demonstrated that the levels of toxic contaminants are below the permitted limits. These impurities are used as reagents or are generated during synthesis. N-bromosuccinim...

  • Article
  • Open Access
13 Citations
2,556 Views
14 Pages

Background: Xiaochaihu capsule is composed of seven traditional Chinese medicines. The pharmacopoeia only focuses on the quantitative detection of baicalin, which cannot fully reflect the quality of the preparation. Some medium polar components were...

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Separations - ISSN 2297-8739