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Children, Volume 12, Issue 11

November 2025 - 153 articles

Cover Story: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are reshaping pediatric obesity and type 2 diabetes management, with approved products offering significant BMI and weight reductions. However, major knowledge gaps remain. Long-term safety and durability of effect in youth are unknown, particularly regarding bone health, lean mass preservation, and neurohormonal development. Optimal dosing, duration, and criteria for treatment discontinuation risk for weight rebound require further study. This review integrates clinical and mechanistic evidence while underscoring the urgent need for longitudinal, pediatric-specific research to inform safe and effective obesity pharmacotherapy in growing children. View this paper
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Articles (153)

  • Article
  • Open Access
276 Views
13 Pages

Role of Matsuda Index in Identifying Patients at Risk for Cystic Fibrosis-Related Diabetes Development

  • Serpil Albayrak,
  • Elif Arık,
  • Özlem Keskin,
  • Murat Karaoğlan,
  • Mehmet Keskin,
  • Gaye İnal,
  • Mahmut Cesur,
  • Ercan Küçükosmanoğlu and
  • Ahmet Yıldırım

18 November 2025

Background: Cystic fibrosis-related diabetes (CFRD) is a frequent comorbidity in individuals with cystic fibrosis (CF). While insulin secretion defects are the primary mechanism in CFRD pathophysiology, insulin resistance may contribute as an additio...

  • Article
  • Open Access
295 Views
13 Pages

Antegrade Continence Enema vs. Botulinum Toxin in Pediatric Chronic Idiopathic Constipation: A 10-Year Retrospective Study at a Single Center

  • Prisca C. Obidike,
  • Trevor C. Jones,
  • Chioma Moneme,
  • Alexander Bills,
  • Zoë Hemmer,
  • Alison Jung,
  • Lillian Wu and
  • Lily S. Cheng

18 November 2025

Introduction: Chronic Idiopathic Constipation (CIC) is a common pediatric gastrointestinal disorder (GI) characterized by persistent difficulty in defecation, with no identifiable underlying cause. Although most patients are successfully treated with...

  • Article
  • Open Access
267 Views
13 Pages

Clinical and Molecular Spectrum of MYH9-Thrombocytopenia: Insights from a Single Centric Pediatric Cohort

  • Radu Obrisca,
  • Andreea Serbanica,
  • Andra Marcu,
  • Ana Bica,
  • Cristina Jercan,
  • Irina Avramescu,
  • Letita Radu,
  • Cerasela Jardan and
  • Anca Colita

17 November 2025

Background: MYH9-related disease (MYH9-RD) is the most common form of inherited thrombocytopenia (IT). It is caused by pathogenic variants in the MYH9 gene. It manifests as early-onset macrothrombocytopenia with variable later-onset extra-hematologic...

  • Article
  • Open Access
307 Views
11 Pages

Surgical Versus Non-Surgical Treatment of Patients with Myopathic Scoliosis: Clinical, Radiological and Functional Outcomes

  • Alexandra Satanovsky,
  • Rana Hanna,
  • Patrice L. Weiss,
  • Amihai Rigbi,
  • Josh E. Schroeder and
  • Sharon Eylon

17 November 2025

Background/Objectives: Myopathies are acquired or genetic muscle diseases causing weakness and wasting, leading to poor posture, impaired coordination, reduced daily function, and scoliosis. The objective of this ambispective study was to compare cli...

  • Article
  • Open Access
472 Views
15 Pages

Food Pattern, Food Selectivity and Sensory Profile in Autism Spectrum Disorder: An Exploratory Analysis in Chilean Children

  • Fernanda Mora,
  • María José Manzur,
  • David Morales-Zepeda,
  • Oscar Flores,
  • Constanza Schwencke and
  • Marcell Leonario-Rodriguez

17 November 2025

Background/Objectives: Introduction: Food selectivity is highly prevalent in children with autism spectrum disorder (ASD) and is associated with sensory hypersensitivity, particularly in oral, olfactory, and tactile domains. Although international ev...

  • Review
  • Open Access
417 Views
25 Pages

Phytotherapy in Pediatric Dentistry: A Narrative Review of Clinical Applications and Evidence

  • Zorela Elena Miclăuș,
  • Rahela Tabita Moca,
  • Ruxandra-Ilinca Matei,
  • Abel Emanuel Moca,
  • Adriana Țenț and
  • Anca Porumb

17 November 2025

Background/Objectives: Phytotherapy, the use of plant-derived bioactive compounds for therapeutic purposes, has gained increasing attention in dentistry as a natural, well-tolerated, and culturally acceptable adjunct to conventional treatments. In pe...

  • Review
  • Open Access
1,119 Views
27 Pages

The Pediatric Microbiota–Gut–Brain Axis: Implications for Neuropsychiatric Development and Intervention

  • Giuseppe Marano,
  • Greta Sfratta,
  • Ester Maria Marzo,
  • Giorgia Cozzo,
  • Francesca Abate,
  • Gianandrea Traversi,
  • Osvaldo Mazza,
  • Esmeralda Capristo,
  • Eleonora Gaetani and
  • Marianna Mazza

17 November 2025

Background: The gut microbiota plays a crucial role in brain development and function, especially in early life. Disruptions in the pediatric microbiota–gut–brain axis have been linked to neurodevelopmental and psychiatric disorders. We h...

  • Article
  • Open Access
307 Views
11 Pages

17 November 2025

Background/Objectives: Children with neurological impairments, especially those who are non-ambulatory, may require additional care services beyond what is available for the general pediatric population, and tracheostomy may be necessary for addressi...

  • Article
  • Open Access
349 Views
17 Pages

17 November 2025

Background/Objectives: Headache attributed to rhinosinusitis (HRS) is uncommon in children but often misdiagnosed as migraine or tension-type headache (TTH). Overlapping phenotypes, incidental sinus findings on neuroimaging, and limited communication...

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Children - ISSN 2227-9067