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Biomedicines, Volume 8, Issue 12

December 2020 - 110 articles

Cover Story: Emerging evidence points toward a role for maternal immune system dysfunctions in autism spectrum disorder (ASD) development. Maternal immune activation, (fetal) brain-reactive antibodies in the maternal plasma, maternal autoantibodies (autoimmune diseases), changes in maternal cytokine levels, and maternal microbiome show associations with ASD in the offspring. View this paper
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Articles (110)

  • Review
  • Open Access
55 Citations
7,909 Views
24 Pages

STAT3 and p53: Dual Target for Cancer Therapy

  • Thu-Huyen Pham,
  • Hyo-Min Park,
  • Jinju Kim,
  • Jin Tae Hong and
  • Do-Young Yoon

The tumor suppressor p53 is considered the “guardian of the genome” that can protect cells against cancer by inducing cell cycle arrest followed by cell death. However, STAT3 is constitutively activated in several human cancers and plays...

  • Article
  • Open Access
34 Citations
4,460 Views
12 Pages

Advanced Glycation End Products (AGE) and Soluble Forms of AGE Receptor: Emerging Role as Mortality Risk Factors in CKD

  • Elena Dozio,
  • Simone Vettoretti,
  • Lara Caldiroli,
  • Silvia Nerini-Molteni,
  • Lorenza Tacchini,
  • Federico Ambrogi,
  • Piergiorgio Messa and
  • Massimiliano M. Corsi Romanelli

Advanced glycation end-products (AGE) can promote chronic kidney disease (CKD) progression and CKD-related morbidities. The soluble receptor for AGE (sRAGE) is a potential biomarker of inflammation and oxidative stress. Here, we explored the role of...

  • Review
  • Open Access
46 Citations
7,323 Views
17 Pages

Endothelial to Mesenchymal Transition in Pulmonary Vascular Diseases

  • Eunsik Yun,
  • Yunjin Kook,
  • Kyung Hyun Yoo,
  • Keun Il Kim,
  • Myeong-Sok Lee,
  • Jongmin Kim and
  • Aram Lee

Lung diseases, such as pulmonary hypertension and pulmonary fibrosis, are life-threatening diseases and have common features of vascular remodeling. During progression, extracellular matrix protein deposition and dysregulation of proteolytic enzymes...

  • Article
  • Open Access
24 Citations
4,937 Views
16 Pages

Oligodendrocytes, the myelinating cells in the central nervous system (CNS), are critical for producing myelin throughout the CNS. The loss of oligodendrocytes is associated with multiple neurodegenerative disorders mediated by psychosine. However, t...

  • Article
  • Open Access
22 Citations
4,688 Views
17 Pages

Biocompatibility and Immune Response of a Newly Developed Volume-Stable Magnesium-Based Barrier Membrane in Combination with a PVD Coating for Guided Bone Regeneration (GBR)

  • Larissa Steigmann,
  • Ole Jung,
  • Wolfgang Kieferle,
  • Sanja Stojanovic,
  • Annica Proehl,
  • Oliver Görke,
  • Steffen Emmert,
  • Stevo Najman,
  • Mike Barbeck and
  • Daniel Rothamel

To date, there are no bioresorbable alternatives to non-resorbable and volume-stable membranes in the field of dentistry for guided bone or tissue regeneration (GBR/GTR). Even magnesium (Mg) has been shown to constitute a favorable biomaterial for th...

  • Article
  • Open Access
4 Citations
3,681 Views
12 Pages

Novel Pathogenic Variants of the AIRE Gene in Two Autoimmune Polyendocrine Syndrome Type I Cases with Atypical Presentation: Role of the NGS in Diagnostic Pathway and Review of the Literature

  • Luigia Cinque,
  • Cristina Angeletti,
  • Alfredo Orrico,
  • Stefano Castellana,
  • Lucia Ferrito,
  • Cristina Ciuoli,
  • Tommaso Mazza,
  • Marco Castori and
  • Vito Guarnieri

Background. Autoimmune polyglandular syndrome type 1 (APS-1) with or without reversible metaphyseal dysplasia is a rare genetic disorder due to inactivating variants of the autoimmune regulator, AIRE, gene. Clinical variability of APS-1 relates to pl...

  • Article
  • Open Access
5 Citations
3,253 Views
12 Pages

Local Vascularization during Orthodontic Tooth Movement in a Split Mouth Rat Model—A MRI Study

  • Peter Proff,
  • Agnes Schröder,
  • Lisa Seyler,
  • Franziska Wolf,
  • Yüksel Korkmaz,
  • Tobias Bäuerle,
  • Lina Gölz and
  • Christian Kirschneck

Orthodontic tooth movement to therapeutically align malpositioned teeth is supposed to impact blood flow in the surrounding tissues. Here, we evaluated actual vascularization in the tension area of the periodontal ligament during experimental tooth m...

  • Review
  • Open Access
47 Citations
7,265 Views
19 Pages

Role of CD146 (MCAM) in Physiological and Pathological Angiogenesis—Contribution of New Antibodies for Therapy

  • Ahmad Joshkon,
  • Xavier Heim,
  • Cléa Dubrou,
  • Richard Bachelier,
  • Wael Traboulsi,
  • Jimmy Stalin,
  • Hussein Fayyad-Kazan,
  • Bassam Badran,
  • Alexandrine Foucault-Bertaud and
  • Aurelie S. Leroyer
  • + 2 authors

The fundamental role of cell adhesion molecules in mediating various biological processes as angiogenesis has been well-documented. CD146, an adhesion molecule of the immunoglobulin superfamily, and its soluble form, constitute major players in both...

  • Article
  • Open Access
5 Citations
4,568 Views
21 Pages

Modulation of Early Host Innate Immune Response by an Avipox Vaccine Virus’ Lateral Body Protein

  • Efstathios S. Giotis,
  • Stephen M. Laidlaw,
  • Susanna R. Bidgood,
  • David Albrecht,
  • Jemima J. Burden,
  • Rebecca C. Robey,
  • Jason Mercer and
  • Michael A. Skinner

The avian pathogen fowlpox virus (FWPV) has been successfully used as a vaccine vector in poultry and humans, but relatively little is known about its ability to modulate host antiviral immune responses in these hosts, which are replication-permissiv...

  • Article
  • Open Access
69 Citations
7,034 Views
13 Pages

Evidence of SARS-CoV-2 Transcriptional Activity in Cardiomyocytes of COVID-19 Patients without Clinical Signs of Cardiac Involvement

  • Gaetano Pietro Bulfamante,
  • Gianluca Lorenzo Perrucci,
  • Monica Falleni,
  • Elena Sommariva,
  • Delfina Tosi,
  • Carla Martinelli,
  • Paola Songia,
  • Paolo Poggio,
  • Stefano Carugo and
  • Giulio Pompilio

Aims: A considerable proportion of patients affected by coronavirus respiratory disease (COVID-19) develop cardiac injury. The viral impact in cardiomyocytes deserves, however, further investigations, especially in asymptomatic patients. Methods: We...

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Biomedicines - ISSN 2227-9059