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Article

Enhancing Mechanical Properties and Biological Performances of Injectable Bioactive Glass by Gelatin and Chitosan for Bone Small Defect Repair

1
School of Metallurgy and Materials Engineering, Iran University of Science and Technology, Tehran 1684613114, Iran
2
Department of Chemistry, Research Laboratory of Green Organic Synthesis and Polymers, Iran University of Science and Technology, Tehran 1684613114, Iran
3
Department of Health Sciences, Center for Translational Research on Autoimmune and Allergic Diseases–CAAD, University of Piemonte Orientale UPO, 28100 Novara, Italy
4
Institute of Materials Engineering and Physics, Department of Applied Science and Technology, Politecnico di Torino, 10129 Turin, Italy
*
Authors to whom correspondence should be addressed.
Biomedicines 2020, 8(12), 616; https://doi.org/10.3390/biomedicines8120616
Received: 4 November 2020 / Revised: 7 December 2020 / Accepted: 13 December 2020 / Published: 15 December 2020
(This article belongs to the Special Issue Bone Tissue Regeneration: Biology and Strategies)
Bioactive glass (BG) represents a promising biomaterial for bone healing; here injectable BG pastes biological properties were improved by the addition of gelatin or chitosan, as well as mechanical resistance was enhanced by adding 10 or 20 wt% 3-Glycidyloxypropyl trimethoxysilane (GPTMS) cross-linker. Composite pastes exhibited bioactivity as apatite formation was observed by Scanning Electron Microscopy (SEM) and X-Ray Diffraction (XRD) after 14 days immersion in simulated body fluid (SBF); moreover, polymers did not enhance degradability as weight loss was >10% after 30 days in physiological conditions. BG-gelatin-20 wt% GPTMS composites demonstrated the highest compressive strength (4.8 ± 0.5 MPa) in comparison with the bulk control paste made of 100% BG in water (1.9 ± 0.1 MPa). Cytocompatibility was demonstrated towards human mesenchymal stem cells (hMSC), osteoblasts progenitors, and endothelial cells. The presence of 20 wt% GPTMS conferred antibacterial properties thus inhibiting the joint pathogens Staphylococcus aureus and Staphylococcus epidermidis infection. Finally, hMSC osteogenesis was successfully supported in a 3D model as demonstrated by alkaline phosphatase release and osteogenic genes expression. View Full-Text
Keywords: bioactive glass; gelatin; chitosan; 3-Glycidyloxypropyl trimethoxysilane; bone bioactive glass; gelatin; chitosan; 3-Glycidyloxypropyl trimethoxysilane; bone
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MDPI and ACS Style

Sohrabi, M.; Eftekhari Yekta, B.; Rezaie, H.; Naimi-Jamal, M.R.; Kumar, A.; Cochis, A.; Miola, M.; Rimondini, L. Enhancing Mechanical Properties and Biological Performances of Injectable Bioactive Glass by Gelatin and Chitosan for Bone Small Defect Repair. Biomedicines 2020, 8, 616. https://doi.org/10.3390/biomedicines8120616

AMA Style

Sohrabi M, Eftekhari Yekta B, Rezaie H, Naimi-Jamal MR, Kumar A, Cochis A, Miola M, Rimondini L. Enhancing Mechanical Properties and Biological Performances of Injectable Bioactive Glass by Gelatin and Chitosan for Bone Small Defect Repair. Biomedicines. 2020; 8(12):616. https://doi.org/10.3390/biomedicines8120616

Chicago/Turabian Style

Sohrabi, Mehri, Bijan Eftekhari Yekta, Hamidreza Rezaie, Mohammad Reza Naimi-Jamal, Ajay Kumar, Andrea Cochis, Marta Miola, and Lia Rimondini. 2020. "Enhancing Mechanical Properties and Biological Performances of Injectable Bioactive Glass by Gelatin and Chitosan for Bone Small Defect Repair" Biomedicines 8, no. 12: 616. https://doi.org/10.3390/biomedicines8120616

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