Novel Anti-cancer Agents and Cellular Targets and Their Mechanism(s) of Action

Dear Colleagues,

The focus of this Special Issue is “Novel Anti-Cancer Agents and Cellular Targets and Their Mechanism(s) of Action”. Whilst there have been significant improvements in treatments and outcomes for some cancers, for others there has been little change in survival rates over many years. Side effects resulting from the toxicity of agents towards normal tissues and the development of drug resistance can be a problem with both targeted and traditional anti-cancer agents. There is a pressing need for new anti-cancer agents with novel mechanism(s) of action and the identification of new putative cellular targets and therapeutic strategies that are both potent and more selective towards cancer cells. This Special Issue invites submissions in any area relating to these themes. Possible topics within this scope include (but are not limited to) the following:

• New promising compounds with in vitro and/or in vivo anti-cancer activity identified through a phenotypic approach, and studies on elucidating their mechanism(s) of action;
• New putative cellular targets that may offer cancer selectivity to targeting approaches (targeted therapies);
• Novel therapeutic approaches, such as combinatorial chemotherapy, that may confer synthetic lethality or improve selectivity;
• Drug re-purposing;
• Promising agents showing polypharmacology;
• Target deconvolution and target validation studies.

 We invite authors to submit original research articles or review articles.

Dr. Simon J Allison
Guest Editor

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