Special Issue "Bone Tissue Regeneration: Biology and Strategies"
A special issue of Biomedicines (ISSN 2227-9059).
Deadline for manuscript submissions: 31 December 2020.
Interests: osteocytes signaling; skeletal/muscle disorders; signal transduction; PI3K/Akt/mTor pathway; hematological diseases
Bone tissue engineering is an exciting approach to directly repair bone defects or engineer bone tissue for transplantation. In the past, the most useful treatments consisted of filling the gap with an autologous bone graft. Recently, the most advanced tissue engineering strategies aim to regenerate impaired tissue using biologically functionalized constructs. The optimal construct should not only be a filler for bone gaps, but it should also mimic the extracellular matrix properties and provide osteogenic stimuli on native bone to trigger/guide the stimulation of the newly forming tissue in vivo. Several techniques were developed to functionalize scaffolds for targeted molecule release to provide the recruitment/proliferation of autologous cells within the implant. However, such techniques offer restricted control on construct geometry, pore size, and internal architecture—crucial features for cell migration abilities. 3D-printing is considered to be a promising method to generate biodegradable supports, to print cells and matrices into a defined geometric area, and to maintain the vascular network next to the regenerating bone. Biomaterials and numerous functionalizing molecules play a pivotal role in providing a template and an extracellular environment to support regenerative cells and promote tissue regeneration. This Special Issue will review biomimetic strategies in developing new biomaterials and constructing signaling delivery systems for bone tissue engineering.
Dr. Jessika Bertacchini
Manuscript Submission Information
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- bone cells
- 3D printing
- tissue regeneration