Special Issue "Bone Tissue Regeneration: Biology and Strategies"

A special issue of Biomedicines (ISSN 2227-9059).

Deadline for manuscript submissions: 31 December 2020.

Special Issue Editor

Dr. Jessika Bertacchini
Guest Editor
Università degli Studi di Modena e Reggio Emilia, Modena, Italy
Interests: osteocytes signaling; skeletal/muscle disorders; signal transduction; PI3K/Akt/mTor pathway; hematological diseases

Special Issue Information

Dear Colleagues,

Bone tissue engineering is an exciting approach to directly repair bone defects or engineer bone tissue for transplantation. In the past, the most useful treatments consisted of filling the gap with an autologous bone graft. Recently, the most advanced tissue engineering strategies aim to regenerate impaired tissue using biologically functionalized constructs. The optimal construct should not only be a filler for bone gaps, but it should also mimic the extracellular matrix properties and provide osteogenic stimuli on native bone to trigger/guide the stimulation of the newly forming tissue in vivo. Several techniques were developed to functionalize scaffolds for targeted molecule release to provide the recruitment/proliferation of autologous cells within the implant. However, such techniques offer restricted control on construct geometry, pore size, and internal architecture—crucial features for cell migration abilities. 3D-printing is considered to be a promising method to generate biodegradable supports, to print cells and matrices into a defined geometric area, and to maintain the vascular network next to the regenerating bone. Biomaterials and numerous functionalizing molecules play a pivotal role in providing a template and an extracellular environment to support regenerative cells and promote tissue regeneration. This Special Issue will review biomimetic strategies in developing new biomaterials and constructing signaling delivery systems for bone tissue engineering.

Dr. Jessika Bertacchini
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • biomaterials
  • scaffold
  • bone cells
  • 3D printing
  • tissue regeneration

Published Papers

This special issue is now open for submission.
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