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Article

Local Vascularization during Orthodontic Tooth Movement in a Split Mouth Rat Model—A MRI Study

1
Department of Orthodontics, University Hospital Regensburg, 93053 Regensburg, Germany
2
Department of Radiology, University Clinic, Friedrich-Alexander-University Erlangen-Nuremberg, 91054 Erlangen, Germany
3
Department of Periodontology and Operative Dentistry, University of Mainz, 55131 Mainz, Germany
4
Department of Orthodontics, University Clinic, Friedrich-Alexander-University Erlangen-Nuremberg, 91054 Erlangen, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Biomedicines 2020, 8(12), 632; https://doi.org/10.3390/biomedicines8120632
Received: 18 November 2020 / Revised: 15 December 2020 / Accepted: 17 December 2020 / Published: 19 December 2020
(This article belongs to the Special Issue Models for Oral Biology Research)
Orthodontic tooth movement to therapeutically align malpositioned teeth is supposed to impact blood flow in the surrounding tissues. Here, we evaluated actual vascularization in the tension area of the periodontal ligament during experimental tooth movement in rats (N = 8) with magnetic resonance imaging (MRI). We inserted an elastic band between the left upper first and the second rat molar; the right side was not treated and served as control. After four days of tooth movement, we recorded T1-weighted morphologic and dynamic-contrast-enhanced MRI sequences with an animal-specific 7 Tesla MRI to assess of local vascularization. Furthermore, we quantified osteoclasts and monocytes in the periodontal ligament, which are crucial for orthodontic tooth movement, root resorptions as undesirable side effects, as well as the extent of tooth movement using paraffine histology and micro-CT analysis. Data were tested for normal distribution with Shapiro–Wilk tests followed by either a two-tailed paired t-test or a Wilcoxon matched-pairs signed rank test. Significant orthodontic tooth movement was induced within the four days of treatment, as evidenced by increased osteoclast and monocyte activity in the periodontal ligament as well as by µCT analysis. Contrast enhancement was increased at the orthodontically-treated side distally of the moved upper first left molar, indicating increased vascularization at the tension side of the periodontal ligament. Accordingly, we detected reduced time-to-peak and washout rates. Our study using MRI to directly assess local vascularization thus seems to confirm the hypothesis that perfusion is enhanced in tension zones of the periodontal ligament during orthodontic tooth movement. View Full-Text
Keywords: magnetic resonance imaging; orthodontic tooth movement; vascularization magnetic resonance imaging; orthodontic tooth movement; vascularization
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MDPI and ACS Style

Proff, P.; Schröder, A.; Seyler, L.; Wolf, F.; Korkmaz, Y.; Bäuerle, T.; Gölz, L.; Kirschneck, C. Local Vascularization during Orthodontic Tooth Movement in a Split Mouth Rat Model—A MRI Study. Biomedicines 2020, 8, 632. https://doi.org/10.3390/biomedicines8120632

AMA Style

Proff P, Schröder A, Seyler L, Wolf F, Korkmaz Y, Bäuerle T, Gölz L, Kirschneck C. Local Vascularization during Orthodontic Tooth Movement in a Split Mouth Rat Model—A MRI Study. Biomedicines. 2020; 8(12):632. https://doi.org/10.3390/biomedicines8120632

Chicago/Turabian Style

Proff, Peter, Agnes Schröder, Lisa Seyler, Franziska Wolf, Yüksel Korkmaz, Tobias Bäuerle, Lina Gölz, and Christian Kirschneck. 2020. "Local Vascularization during Orthodontic Tooth Movement in a Split Mouth Rat Model—A MRI Study" Biomedicines 8, no. 12: 632. https://doi.org/10.3390/biomedicines8120632

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