Angiogenesis and Inflammation in Biological Barriers

Dear Colleagues,

This Special Issue will gather publications that focus on two key processes, angiogenesis and inflammation, which strongly contribute to the functioning of highly vascularized biological barriers (BB), such as the brain (BBB), lung (LB), and placenta (PB) barriers.

Biological barriers are essential for the integrity and proper function of many vertebrate organs and are critical for the regulation of tissue homeostasis and protection against pathogens or other tissue-damaging agents. BB separate internal and external compartments and are formed by specialized cell types, such as epithelial and endothelial cells, that interface the body and the external environment. The LB, PB, and BBB are three highly vascularized entities relying on fine communications between endothelial and neighboring cells. Processes such as vascularization, angiogenesis, and inflammation play major roles in the control of the integrity of these barriers. Specialized pro- and anti-angiogenic and inflammatory factors control these processes. The latter includes the inflammasome family. Recent studies have also reported the involvement of new factors that control both angiogenic and inflammatory processes, such as the prokineticin family. Failure in the expression of these factors and/or impaired epithelial–endothelial barrier function are major hallmarks of several barrier-associated pathologies, including infection, exacerbated inflammation, tissue injury, and tumor development. This Special Issue welcomes original articles and reviews focused on angiogenesis and inflammation in highly vascularized biological barriers.

Dr. Nadia Alfaidy
Guest Editor

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