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Biomedicines, Volume 11, Issue 12

December 2023 - 247 articles

Cover Story: The disease concept of “dysuricemia” includes hyperuricemia and hypouricemia. Both influence diseases in humans. Uric acid plays dual roles in oxidative stress: it has both an anti-oxidative protective effect and a pro-oxidative and/or a harmful crystal-forming effect. Extensive research on the relationship between the serum urate (SU) level and several common disease risks show characteristic patterns that are broadly classifiable into three patterns: the “gout pattern,” “neurodegenerative disease (ND) pattern,” and “chronic kidney disease (CKD) and cardiovascular disease (CVD) pattern”. In short, “the lower, the better” is incorrect; the ideal is to maintain normouricemia, or an optimal SU level, to reduce the risks of the common diseases associated with dysuricemia. View this paper
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Articles (247)

  • Article
  • Open Access
5 Citations
2,188 Views
17 Pages

Clinical and Microbiological Impact of Implementing a Decision Support Algorithm through Microbiologic Rapid Diagnosis in Critically Ill Patients: An Epidemiological Retrospective Pre-/Post-Intervention Study

  • Alejandro Rodríguez,
  • Frederic Gómez,
  • Carolina Sarvisé,
  • Cristina Gutiérrez,
  • Montserrat Galofre Giralt,
  • María Dolores Guerrero-Torres,
  • Sergio Pardo-Granell,
  • Ester Picó-Plana,
  • Clara Benavent-Bofill and
  • Sandra Trefler
  • + 10 authors

16 December 2023

Background: Data on the benefits of rapid microbiological testing on antimicrobial consumption (AC) and antimicrobial resistance patterns (ARPs) are scarce. We evaluated the impact of a protocol based on rapid techniques on AC and ARP in intensive ca...

  • Article
  • Open Access
1 Citations
1,811 Views
12 Pages

Determining Thrombogenicity: Using a Modified Thrombin Generation Assay to Detect the Level of Thrombotic Event Risk in Lupus Anticoagulant-Positive Patients

  • Pavla Bradáčová,
  • Luděk Slavík,
  • Jana Úlehlová,
  • Eva Kriegová,
  • Eliška Jará,
  • Lenka Bultasová,
  • David Friedecký,
  • Jana Ullrychová,
  • Jana Procházková and
  • Antonín Hluší
  • + 2 authors

16 December 2023

The aim of this study was to determine the thrombogenicity of lupus anticoagulant (LA) antibodies using a modified thrombin generation assay (TGA) with the addition of activated protein C (APC) in a group of 85 patients with LA-positive samples. Of t...

  • Review
  • Open Access
3 Citations
2,997 Views
32 Pages

Neuromodulation for Craniofacial Pain and Headaches

  • Ray J. Pak,
  • Jun B. Ku and
  • Alaa Abd-Elsayed

16 December 2023

Headaches and facial pain are highly prevalent diseases but are often difficult to treat. Though there have been significant advances in medical management, many continue to suffer from refractory pain. Neuromodulation has been gaining interest for i...

  • Article
  • Open Access
1 Citations
1,751 Views
13 Pages

Studying Erythromelalgia Using Doppler Flowmetry Perfusion Signals and Wavelet Analysis—An Exploratory Study

  • Luis Monteiro Rodrigues,
  • Joana Caetano,
  • Sergio Faloni Andrade,
  • Clemente Rocha,
  • José Delgado Alves and
  • Hugo Alexandre Ferreira

16 December 2023

Erythromelalgia (EM) is a rare disease, which is still poorly characterized. In the present paper, we compared the hand perfusion of one female EM patient, under challenges, with a healthy control group. Using a laser Doppler flowmeter (LDF) with an...

  • Review
  • Open Access
14 Citations
6,123 Views
19 Pages

16 December 2023

As an immune checkpoint molecule, CD200 serves a foundational role in regulating immune homeostasis and promoting self-tolerance. While CD200 expression occurs in various immune cell subsets and normal tissues, its aberrant expression patterns in hem...

  • Article
  • Open Access
4 Citations
2,160 Views
18 Pages

16 December 2023

Indole-3-acetonitrile, a compound produced by bacteria and plants as a defense and survival signal in response to attacks, has been recently discovered as a metabolite produced by human cancer cells. This discovery suggests a potential association be...

  • Article
  • Open Access
6 Citations
2,466 Views
12 Pages

Dapagliflozin Ameliorates Neural Damage in the Heart and Kidney of Diabetic Mice

  • Ionuț Donoiu,
  • Georgică Târtea,
  • Veronica Sfredel,
  • Victor Raicea,
  • Anca Maria Țucă,
  • Alexandra Nicoleta Preda,
  • Dragoş Cozma and
  • Radu Vătășescu

16 December 2023

(1) Background: Measures for the control of diabetes mellitus (DM) and, especially, for the control of its complications represent a main objective of the research carried out on this disease, since both mortality and morbidity relating to DM represe...

  • Article
  • Open Access
6 Citations
14,943 Views
13 Pages

Enalapril Is Superior to Lisinopril in Improving Endothelial Function without a Difference in Blood–Pressure–Lowering Effects in Newly Diagnosed Hypertensives

  • Attila Nagy,
  • Réka Májer,
  • Judit Boczán,
  • Sándor Sipka,
  • Attila Szabó,
  • Enikő Edit Enyedi,
  • Ottó Tatai,
  • Miklós Fagyas,
  • Zoltán Papp and
  • László Csiba
  • + 1 author

15 December 2023

Angiotensin–converting enzyme (ACE) inhibitors are the primarily chosen drugs to treat various cardiovascular diseases, such as hypertension. Although the most recent guidelines do not differentiate among the various ACE inhibitory drugs, there...

  • Article
  • Open Access
3 Citations
2,350 Views
14 Pages

Farnesol Inhibits PI3 Kinase Signaling and Inflammatory Gene Expression in Primary Human Renal Epithelial Cells

  • Aline Müller,
  • Maria Lozoya,
  • Xiaoying Chen,
  • Volkmar Weissig and
  • Mahtab Nourbakhsh

15 December 2023

Chronic inflammation and elevated cytokine levels are closely associated with the progression of chronic kidney disease (CKD), which is responsible for the manifestation of numerous complications and mortality. In addition to conventional CKD therapi...

  • Article
  • Open Access
2 Citations
2,154 Views
13 Pages

Skin Bioimpedance Analysis to Determine Cellular Integrity by Phase Angle in Women with Fibromyalgia: A Cross-Sectional Study

  • Davinia Vicente-Campos,
  • Sandra Sánchez-Jorge,
  • Luis Martí,
  • Jorge Buffet,
  • Nuria Mendoza-Laiz,
  • David Rodriguez-Sanz,
  • Ricardo Becerro-de-Bengoa-Vallejo,
  • J. L. Chicarro and
  • César Calvo-Lobo

15 December 2023

Oxidative stress has been proposed as a significant part of the pathogenesis of fibromyalgia, and the phase angle in bioelectrical impedance analysis has been explored as a potential technique to screen oxidative abnormalities. This study recruited 3...

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Biomedicines - ISSN 2227-9059