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Article

Ellagitannin, Phenols, and Flavonoids as Antibacterials from Acalypha arvensis (Euphorbiaceae)

by
Ever A. Ble-González
1,*,
Abraham Gómez-Rivera
1,
Alejandro Zamilpa
2,
Ricardo López-Rodríguez
1,
Carlos Ernesto Lobato-García
1,
Patricia Álvarez-Fitz
3,
Ana Silvia Gutierrez-Roman
2,
Ma Dolores Perez-García
2,
Alejandro Bugarin
4 and
Manasés González-Cortazar
2,*
1
División Académica de Ciencias Básicas, Universidad Juárez Autónoma de Tabasco, Carretera Cunduacán-Jalpa Km. 0.5, Cunduacán 86690, Tabasco, Mexico
2
Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec 62790, Morelos, Mexico
3
Laboratorio de Toxicología, Cátedra CONACyT-Universidad Autónoma de Guerrero, Av. Lázaro Cárdenas s/n. Col. La Haciendita, Chilpancingo 39070, Guerrero, Mexico
4
Department of Chemistry and Physics, Florida Gulf Coast University, Fort Myers, FL 33965, USA
*
Authors to whom correspondence should be addressed.
Plants 2022, 11(3), 300; https://doi.org/10.3390/plants11030300
Submission received: 13 December 2021 / Revised: 12 January 2022 / Accepted: 13 January 2022 / Published: 24 January 2022
(This article belongs to the Special Issue Plant Therapeutics)
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Abstract

There is a significant need to gain access to new and better antibacterial agents. Acalypha arvensis, a plant from the Euphorbiaceae family, has been used in traditional medicine for centuries to treat infectious diseases. This manuscript reports the isolation, characterization, and antibacterial screening of 8 natural products extracted from maceration of aerial parts of Acalypha arvensis. Specifically, three extracts were assessed (n-hexane, ethyl acetate, and ethanol), in which antibacterial activity was evaluated against diverse bacterial strains. The ethanolic extract showed the best activity against methicillin-sensitive and methicillin-resistant Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa strains, which supports the medicinal properties attributed to this plant. The chromatographic fractions AaR4 and AaR5 were the most bioactive, in which the ellagitannin natural product known as corilagin (1) was identified for the first time in this plant. Therefore, it can be said that this is the main chemical responsible for the observed antibacterial activity. However, we also identified chlorogenic acid (2), rutin (3), quercetin-3-O-glucoside (4), caffeic acid (5), among others (6–8). Hence, this plant can be considered to be a good alternative to treat health-related issues caused by various bacteria.
Keywords: Acalypha arvensis; ellagitannin; corilagin; Staphylococcus aureus; flavonoids; antibacterial Acalypha arvensis; ellagitannin; corilagin; Staphylococcus aureus; flavonoids; antibacterial
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MDPI and ACS Style

Ble-González, E.A.; Gómez-Rivera, A.; Zamilpa, A.; López-Rodríguez, R.; Lobato-García, C.E.; Álvarez-Fitz, P.; Gutierrez-Roman, A.S.; Perez-García, M.D.; Bugarin, A.; González-Cortazar, M. Ellagitannin, Phenols, and Flavonoids as Antibacterials from Acalypha arvensis (Euphorbiaceae). Plants 2022, 11, 300. https://doi.org/10.3390/plants11030300

AMA Style

Ble-González EA, Gómez-Rivera A, Zamilpa A, López-Rodríguez R, Lobato-García CE, Álvarez-Fitz P, Gutierrez-Roman AS, Perez-García MD, Bugarin A, González-Cortazar M. Ellagitannin, Phenols, and Flavonoids as Antibacterials from Acalypha arvensis (Euphorbiaceae). Plants. 2022; 11(3):300. https://doi.org/10.3390/plants11030300

Chicago/Turabian Style

Ble-González, Ever A., Abraham Gómez-Rivera, Alejandro Zamilpa, Ricardo López-Rodríguez, Carlos Ernesto Lobato-García, Patricia Álvarez-Fitz, Ana Silvia Gutierrez-Roman, Ma Dolores Perez-García, Alejandro Bugarin, and Manasés González-Cortazar. 2022. "Ellagitannin, Phenols, and Flavonoids as Antibacterials from Acalypha arvensis (Euphorbiaceae)" Plants 11, no. 3: 300. https://doi.org/10.3390/plants11030300

APA Style

Ble-González, E. A., Gómez-Rivera, A., Zamilpa, A., López-Rodríguez, R., Lobato-García, C. E., Álvarez-Fitz, P., Gutierrez-Roman, A. S., Perez-García, M. D., Bugarin, A., & González-Cortazar, M. (2022). Ellagitannin, Phenols, and Flavonoids as Antibacterials from Acalypha arvensis (Euphorbiaceae). Plants, 11(3), 300. https://doi.org/10.3390/plants11030300

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