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Article

Plasma Levels of sFas-sFasL and FASL Gene Expression Are Associated with Tuberculosis

by
Iury de Paula Souza
1,2,†,
Ednelza da Silva Graça Amoras
1,†,
Francisca Dayse Martins de Sousa
1,2,
Paulo Victor Negrão Raiol de Sousa
1,
Sandra Souza Lima
1,
Izaura Maria Vieira Cayres-Vallinoto
1,
Ricardo Ishak
1,
Antonio Carlos Rosário Vallinoto
1 and
Maria Alice Freitas Queiroz
1,*
1
Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém 66075-110, Brazil
2
Graduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém 66075-110, Brazil
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Biomolecules 2023, 13(1), 80; https://doi.org/10.3390/biom13010080
Submission received: 7 November 2022 / Revised: 2 December 2022 / Accepted: 5 December 2022 / Published: 30 December 2022
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Abstract

Apoptosis of macrophages infected by Mycobacterium tuberculosis via Fas-FasL is an important immune mechanism against infection. This study investigated the association of tuberculosis (TB) with the presence of the polymorphisms FAS -670A/G and FASL -124A/G, the levels of sFas and sFasL, and the gene expression of FASL and cytokines. Samples of 200 individuals diagnosed with TB and 200 healthy controls were evaluated. Real-time PCR (genotyping and gene expression) and ELISA (dosages of sFas, sFasL, IFN-γ, and IL-10) tests were performed. There was no association of FAS -670A/G and FASL -124A/G polymorphisms with TB. The TB group exhibited high plasma levels of sFas and reduced plasma levels of sFasL (p < 0.05). The correlation analysis between these markers revealed a positive correlation between the levels of sFas and sFasL, sFasL and FASL expression, and between sFas and FASL expression (p < 0.05). In the TB group, there was a positive correlation between FASL expression and IFN-γ levels and higher levels of IL-10 compared to IFN-γ (p < 0.05). High levels of sFas and reduced levels of sFasL and FASL expression may contribute to the inhibition of apoptosis in infected cells and represent a possible bacterial resistance resource to maintain the infection.
Keywords: Mycobacterium tuberculosis; tuberculosis; FasL; sFas; sFasL; apoptosis Mycobacterium tuberculosis; tuberculosis; FasL; sFas; sFasL; apoptosis

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MDPI and ACS Style

Souza, I.d.P.; Amoras, E.d.S.G.; Sousa, F.D.M.d.; Sousa, P.V.N.R.d.; Lima, S.S.; Cayres-Vallinoto, I.M.V.; Ishak, R.; Vallinoto, A.C.R.; Queiroz, M.A.F. Plasma Levels of sFas-sFasL and FASL Gene Expression Are Associated with Tuberculosis. Biomolecules 2023, 13, 80. https://doi.org/10.3390/biom13010080

AMA Style

Souza IdP, Amoras EdSG, Sousa FDMd, Sousa PVNRd, Lima SS, Cayres-Vallinoto IMV, Ishak R, Vallinoto ACR, Queiroz MAF. Plasma Levels of sFas-sFasL and FASL Gene Expression Are Associated with Tuberculosis. Biomolecules. 2023; 13(1):80. https://doi.org/10.3390/biom13010080

Chicago/Turabian Style

Souza, Iury de Paula, Ednelza da Silva Graça Amoras, Francisca Dayse Martins de Sousa, Paulo Victor Negrão Raiol de Sousa, Sandra Souza Lima, Izaura Maria Vieira Cayres-Vallinoto, Ricardo Ishak, Antonio Carlos Rosário Vallinoto, and Maria Alice Freitas Queiroz. 2023. "Plasma Levels of sFas-sFasL and FASL Gene Expression Are Associated with Tuberculosis" Biomolecules 13, no. 1: 80. https://doi.org/10.3390/biom13010080

APA Style

Souza, I. d. P., Amoras, E. d. S. G., Sousa, F. D. M. d., Sousa, P. V. N. R. d., Lima, S. S., Cayres-Vallinoto, I. M. V., Ishak, R., Vallinoto, A. C. R., & Queiroz, M. A. F. (2023). Plasma Levels of sFas-sFasL and FASL Gene Expression Are Associated with Tuberculosis. Biomolecules, 13(1), 80. https://doi.org/10.3390/biom13010080

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