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Biomolecules, Volume 10, Issue 7
July 2020 - 119 articles
Cover Story: Modifications greatly influence many aspects of tRNA structure and function. Bacillus subtilis sp subtilis strain 168 is the model gram-positive bacteria and the list of genes involved in tRNA modifications in this organism is far from complete. Mass spectrometry analysis of bulk tRNA extracted from B. subtilis combined with next-generation sequencing technologies and comparative genomic analyses have led to the identification of 41 tRNA modification genes with associated confidence scores. This work presents the most up-to-date list of tRNA modification genes in B. subtilis, identifies the gaps in knowledge, and lays the foundation for further work to decipher the physiological role of tRNA modifications in this important model organism. View this paper
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Biomolecules - ISSN 2218-273XCreative Common CC BY license