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Review

Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends

by
Hardeep Singh Tuli
1,*,
Prangya Rath
2,
Abhishek Chauhan
3,
Anuj Ranjan
4,
Seema Ramniwas
5,
Katrin Sak
6,
Diwakar Aggarwal
1,
Manoj Kumar
7,
Kuldeep Dhama
8,
E Hui Clarissa Lee
9,10,
Kenneth Chun-Yong Yap
9,10,
Sharah Mae Capinpin
9,10 and
Alan Prem Kumar
9,10,*
1
Department of Biotechnology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala 133207, India
2
Amity Institute of Environmental Sciences, Amity University, Noida 201303, India
3
Amity Institute of Environmental Toxicology, Safety and Management, Amity University, Noida 201303, India
4
Academy of Biology and Biotechnology, Southern Federal University, 344090 Rostov-on-Don, Russia
5
University Centre for Research and Development, University Institute of Pharmaceutical Sciences, Chandigarh University, Mohali 140413, India
6
NGO Praeventio, 50407 Tartu, Estonia
7
Department of Chemistry, Maharishi Markandeshwar University Sadopur, Ambala 134007, India
8
Division of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly 243122, India
9
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore
10
NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore
*
Authors to whom correspondence should be addressed.
Biomolecules 2023, 13(1), 57; https://doi.org/10.3390/biom13010057
Submission received: 29 November 2022 / Revised: 21 December 2022 / Accepted: 22 December 2022 / Published: 27 December 2022
(This article belongs to the Collection Feature Papers in Section 'Molecular Medicine')
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Abstract

Cucurbitacins constitute a group of cucumber-derived dietary lipids, highly oxidized tetracyclic triterpenoids, with potential medical uses. These compounds are known to interact with a variety of recognized cellular targets to impede the growth of cancer cells. Accumulating evidence has suggested that inhibition of tumor cell growth via induction of apoptosis, cell-cycle arrest, anti-metastasis and anti-angiogenesis are major promising chemo-preventive actions of cucurbitacins. Cucurbitacins may be a potential choice for investigations of synergism with other drugs to reverse cancer cells’ treatment resistance. The detailed molecular mechanisms underlying these effects include interactions between cucurbitacins and numerous cellular targets (Bcl-2/Bax, caspases, STAT3, cyclins, NF-κB, COX-2, MMP-9, VEGF/R, etc.) as well as control of a variety of intracellular signal transduction pathways. The current study is focused on the efforts undertaken to find possible molecular targets for cucurbitacins in suppressing diverse malignant processes. The review is distinctive since it presents all potential molecular targets of cucurbitacins in cancer on one common podium.
Keywords: cucurbitacins; anti-proliferation; apoptotic; anti-angiogenic; anti-metastatic; synergism cucurbitacins; anti-proliferation; apoptotic; anti-angiogenic; anti-metastatic; synergism

Share and Cite

MDPI and ACS Style

Tuli, H.S.; Rath, P.; Chauhan, A.; Ranjan, A.; Ramniwas, S.; Sak, K.; Aggarwal, D.; Kumar, M.; Dhama, K.; Lee, E.H.C.; et al. Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends. Biomolecules 2023, 13, 57. https://doi.org/10.3390/biom13010057

AMA Style

Tuli HS, Rath P, Chauhan A, Ranjan A, Ramniwas S, Sak K, Aggarwal D, Kumar M, Dhama K, Lee EHC, et al. Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends. Biomolecules. 2023; 13(1):57. https://doi.org/10.3390/biom13010057

Chicago/Turabian Style

Tuli, Hardeep Singh, Prangya Rath, Abhishek Chauhan, Anuj Ranjan, Seema Ramniwas, Katrin Sak, Diwakar Aggarwal, Manoj Kumar, Kuldeep Dhama, E Hui Clarissa Lee, and et al. 2023. "Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends" Biomolecules 13, no. 1: 57. https://doi.org/10.3390/biom13010057

APA Style

Tuli, H. S., Rath, P., Chauhan, A., Ranjan, A., Ramniwas, S., Sak, K., Aggarwal, D., Kumar, M., Dhama, K., Lee, E. H. C., Yap, K. C.-Y., Capinpin, S. M., & Kumar, A. P. (2023). Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends. Biomolecules, 13(1), 57. https://doi.org/10.3390/biom13010057

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