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Metabolites, Volume 12, Issue 9

September 2022 - 110 articles

Cover Story: Admission-based circulating biomarkers for the prediction of outcomes in trauma patients could be useful for clinical decision support. Here, we analyzed a large multi-omic database of over 8500 markers (proteomics, metabolomics, and lipidomics) to identify prognostic biomarkers in the circulating compartment for adverse outcomes, including mortality and slow recovery, in severely injured trauma patients. Admission plasma samples from patients (n = 129) enrolled in the Prehospital Air Medical Plasma (PAMPer) trial were analyzed using mass spectrometry (metabolomics and lipidomics) and aptamer-based (proteomics) assays. Our findings indicate that multi-omic analyses can identify novel admission-based prognostic biomarkers for outcomes in trauma patients. Unique biomarker discovery also has the potential to provide biologic insights. View this paper
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Articles (110)

  • Article
  • Open Access
5 Citations
2,555 Views
12 Pages

Non-Invasive Differential Diagnosis of Cervical Neoplastic Lesions by the Lipid Profile Analysis of Cervical Scrapings

  • Alisa Tokareva,
  • Vitaliy Chagovets,
  • Djamilja Attoeva,
  • Natalia Starodubtseva,
  • Niso Nazarova,
  • Kirill Gusakov,
  • Eugenii Kukaev,
  • Vladimir Frankevich and
  • Gennady Sukhikh

19 September 2022

Cervical cancer is one of the most common cancers in women with pronounced stages of precancerous lesions. Accurate differential diagnosis of such lesions is one of the primary challenges of medical specialists, which is vital to improving patient su...

  • Article
  • Open Access
6 Citations
3,139 Views
24 Pages

Impaired Neurovascular Function Underlies Poor Neurocognitive Outcomes and Is Associated with Nitric Oxide Bioavailability in Congenital Heart Disease

  • Vanessa J. Schmithorst,
  • Phillip S. Adams,
  • Daryaneh Badaly,
  • Vincent K. Lee,
  • Julia Wallace,
  • Nancy Beluk,
  • Jodie K. Votava-Smith,
  • Jacqueline G. Weinberg,
  • Sue R. Beers and
  • Jon Detterich
  • + 3 authors

19 September 2022

We use a non-invasive MRI proxy of neurovascular function (pnvf) to assess the ability of the vasculature to supply baseline metabolic demand, to compare pediatric and young adult congenital heart disease (CHD) patients to normal referents and relate...

  • Article
  • Open Access
7 Citations
3,385 Views
16 Pages

Association of Metabolic Signatures with Nonalcoholic Fatty Liver Disease in Pediatric Population

  • Woori Chae,
  • Kyung Jae Lee,
  • Ki Young Huh,
  • Jin Soo Moon,
  • Jae Sung Ko and
  • Joo-Youn Cho

19 September 2022

Several adult omics studies have been conducted to understand the pathophysiology of nonalcoholic fatty liver disease (NAFLD). However, the histological features of children are different from those of adults, and the onset and progression of pediatr...

  • Article
  • Open Access
2,549 Views
9 Pages

A Feasibility Study to Evaluate Changes in Urinary Metabolites after OnabotulinumtoxinA Injection for Refractory Overactive Bladder

  • Laura M. Tellechea,
  • Samantha Freeman,
  • Ilir Agalliu,
  • Melissa A. Laudano,
  • Sylvia O. Suadicani and
  • Nitya Abraham

19 September 2022

Metabolomics analysis of urine before and after overactive bladder (OAB) treatment may demonstrate a unique molecular profile, allowing predictions of responses to treatment. This feasibility study aimed to correlate changes in urinary metabolome wit...

  • Article
  • Open Access
7 Citations
3,261 Views
18 Pages

RETRACTED: In Vitro Induction of Apoptosis in Isolated Acute Myeloid Leukemia Cells: The Role of Anastatica hierochuntica Methanolic Extract

  • Islam M. El-Garawani,
  • Amira S. Abd El-Gaber,
  • Noura A. Algamdi,
  • Aamer Saeed,
  • Chao Zhao,
  • Omar M. Khattab,
  • Mohamed F. AlAjmi,
  • Zhiming Guo,
  • Shaden A. M. Khalifa and
  • Hesham R. El-Seedi

17 September 2022

Anastatica hierochuntica L. (Cruciferae) has been known in Egyptian folk medicine as a remedy for gastrointestinal disorders, diabetes and heart diseases. Despite the wide usage, A. hierochuntica research provides insufficient data to support its tra...

  • Review
  • Open Access
12 Citations
3,064 Views
12 Pages

17 September 2022

Autophagy is an important cellular process, involving the transportation of cytoplasmic contents in the double membrane vesicles to lysosomes for degradation. Autophagy disorder contributes to many diseases, such as immune dysfunction, cancers and ne...

  • Communication
  • Open Access
4 Citations
2,361 Views
7 Pages

Angiopoietin-Like 4 (ANGPTL4) in Patients with Psoriasis, Lichen Planus and Vitiligo—A Pilot Study from the Bialystok+ Polish Longitudinal University Study

  • Julia Nowowiejska,
  • Anna Baran,
  • Justyna Magdalena Hermanowicz,
  • Joanna Mikłosz,
  • Karol Adam Kamiński,
  • Marcin Kondraciuk,
  • Marlena Dubatówka,
  • Dariusz Pawlak and
  • Iwona Flisiak

17 September 2022

Psoriasis, vitiligo and lichen planus (LP) are autoimmune skin diseases associated with metabolic syndrome. Angiopoietin-like 4 (ANGPTL4) is a member of angiopoietin-like proteins, which play an important role in lipid metabolism, and its serum conce...

  • Review
  • Open Access
34 Citations
5,007 Views
23 Pages

16 September 2022

Folate is vital for biological processes within the body, including DNA synthesis, DNA repair, and methylation reactions that metabolize homocysteine. The role of folate is particularly important in pregnancy, where there is rapid cellular and tissue...

  • Article
  • Open Access
7 Citations
2,369 Views
9 Pages

16 September 2022

The single nucleotide polymorphism (SNP) rs4148727 in ABCB1 (encoding p-glycoprotein) is associated with lipid levels; however, its association with type 2 diabetes (T2DM) and its the genetic correlation with lipid profiles and T2DM are unclear. We i...

  • Review
  • Open Access
21 Citations
4,404 Views
28 Pages

Seleno-Metabolites and Their Precursors: A New Dawn for Several Illnesses?

  • Cristina Morán-Serradilla,
  • Eduardo Angulo-Elizari,
  • Andreina Henriquez-Figuereo,
  • Carmen Sanmartín,
  • Arun K. Sharma and
  • Daniel Plano

16 September 2022

Selenium (Se) is an essential element for human health as it is involved in different physiological functions. Moreover, a great number of Se compounds can be considered potential agents in the prevention and treatment of some diseases. It is widely...

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Metabolites - ISSN 2218-1989