Next Article in Journal
Serum Oxylipin Profiles Identify Potential Biomarkers in Patients with Acute Aortic Dissection
Previous Article in Journal
Ring Trial on Quantitative Assessment of Bile Acids Reveals a Method- and Analyte-Specific Accuracy and Reproducibility
Previous Article in Special Issue
Glutamate Efflux across the Blood–Brain Barrier: New Perspectives on the Relationship between Depression and the Glutamatergic System
Article

Effects of Selen on the Antidepressant-like Activity of Agents Affecting the Adenosinergic Neurotransmission

1
Laboratory of Preclinical Testing, Chair and Department of Applied and Social Pharmacy, Medical University of Lublin, 1 Chodźki Street, 20-093 Lublin, Poland
2
Chair and Department of Toxicology, Medical University of Lublin, 8 Chodźki Street, 20-093 Lublin, Poland
3
Chair and Department of Applied and Social Pharmacy, Medical University of Lublin, 1 Chodźki Street, 20-093 Lublin, Poland
4
Clinical Department of Toxicology and Cardiology, Stefan Wyszyński Regional Specialist Hospital in Lublin, Al. Kraśnicka 100, 20-550 Lublin, Poland
5
Toxicology Clinic, Medical University of Lublin, Al. Kraśnicka 100, 20-550 Lublin, Poland
*
Authors to whom correspondence should be addressed.
Academic Editor: Silvia Ravera
Metabolites 2022, 12(7), 586; https://doi.org/10.3390/metabo12070586
Received: 31 May 2022 / Revised: 18 June 2022 / Accepted: 20 June 2022 / Published: 23 June 2022
(This article belongs to the Special Issue Altered Metabolism in Depressive Disorders)
The main goal of this study was to determine the antidepressant-like potential of the co-administration of sodium selenite (Se) and the selective adenosine A1 and A2A antagonists DPCPX and istradefylline (IST), respectively, in mice despair tests. Biochemical studies were performed to elucidate the action mechanisms of the investigated treatment strategies. The results confirmed that, when administered by itself, Se exerts an antidepressant-like effect in the FST and TST and that this activity is dose-dependent. Further experiments demonstrated that Se (0.25 mg/kg) significantly enhanced the activity of mice in both tests when co-administered with DPCPX (1 mg/kg) and IST (0.5 mg/kg) at doses which would be ineffective if administered individually. Our research revealed that neither DPCPX, IST, nor Se or combinations of the tested substances induced significant changes in the brain-derived neurotrophic factor (BDNF) levels in mice serum vs. the NaCl-treated group. However, we observed a decrease in the mRNA level of antioxidant defense enzymes. Molecular studies also showed changes in the expression of the Slc6a15, Comt, and Adora1 genes, particularly after exposure to the combination of Se and DPCPX, which indicates a beneficial effect and may help to explain the key mechanism of the antidepressant effect. The combination of Se with substances attenuating adenosine neurotransmission may become a new therapeutic strategy for patients with depression. View Full-Text
Keywords: selective antagonist of adenosine receptors; DPCPX; istradefylline; sodium selenite; forced swim test; tail suspension test; BDNF; gene expression; mice selective antagonist of adenosine receptors; DPCPX; istradefylline; sodium selenite; forced swim test; tail suspension test; BDNF; gene expression; mice
Show Figures

Figure 1

MDPI and ACS Style

Szopa, A.; Herbet, M.; Poleszak, E.; Bogatko, K.; Ostrowska-Leśko, M.; Świąder, K.; Szponar, J.; Serefko, A. Effects of Selen on the Antidepressant-like Activity of Agents Affecting the Adenosinergic Neurotransmission. Metabolites 2022, 12, 586. https://doi.org/10.3390/metabo12070586

AMA Style

Szopa A, Herbet M, Poleszak E, Bogatko K, Ostrowska-Leśko M, Świąder K, Szponar J, Serefko A. Effects of Selen on the Antidepressant-like Activity of Agents Affecting the Adenosinergic Neurotransmission. Metabolites. 2022; 12(7):586. https://doi.org/10.3390/metabo12070586

Chicago/Turabian Style

Szopa, Aleksandra, Mariola Herbet, Ewa Poleszak, Karolina Bogatko, Marta Ostrowska-Leśko, Katarzyna Świąder, Jarosław Szponar, and Anna Serefko. 2022. "Effects of Selen on the Antidepressant-like Activity of Agents Affecting the Adenosinergic Neurotransmission" Metabolites 12, no. 7: 586. https://doi.org/10.3390/metabo12070586

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop