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Scientia Pharmaceutica, Volume 91, Issue 4

2023 December - 12 articles

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Articles (12)

  • Article
  • Open Access
2,848 Views
11 Pages

STAT3 Inhibitory Activities of Lignans Isolated from the Stems of Lindera obtusiloba Blume

  • Eun-Jae Park,
  • Hee Ju Lim,
  • Hyung Jin Lim,
  • Bong-Sik Yun,
  • Soyoung Lee,
  • Seung-Jae Lee and
  • Seung Woong Lee

8 December 2023

Lindera obtusiloba Blume has several activities, such as anti-inflammatory, anti-allergic, anti-tumor, anti-wrinkle, and antioxidant activities. Interleukin-6 (IL-6) is a classic pro-inflammatory cytokine that is associated with various functions, su...

  • Article
  • Open Access
4 Citations
6,052 Views
13 Pages

Analysis of Beneficial Effects of Flavonoids in Patients with Atherosclerosis Risk on Blood Pressure or Cholesterol during Random Controlled Trials: A Systematic Review and Meta-Analysis

  • Rosa Edith Grijalva-Guiza,
  • Thais Lucía Grijalva-Montano,
  • Mariana Cuautle,
  • Enrique Quiroga-González,
  • Luis Ricardo Hernández,
  • Alicia Ortega Aguilar and
  • Aura Matilde Jiménez-Garduño

22 November 2023

Flavonoids are plant-secondary metabolites with cardiovascular protective properties. Few studies have examined specific flavonoid classes or pure flavonoids concerning some common cardiovascular risks. To obtain information in a systematic review to...

  • Article
  • Open Access
5 Citations
3,994 Views
16 Pages

Monitoring Cutaneous Leishmaniasis Lesions in Mice Undergoing Topical Miltefosine Treatment

  • Laura Fernanda Neira,
  • Julio Cesar Mantilla and
  • Patricia Escobar

9 November 2023

A study was conducted on BALB/c mice infected with Leishmania (Leishmania) amazonensis to analyse the effects of 0.5% miltefosine (MTF) hydrogel treatment on cutaneous leishmaniasis (CL) lesions. The mice were treated for 25 days topically, and lesio...

  • Review
  • Open Access
7 Citations
18,785 Views
39 Pages

Natural Products for the Treatment of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review

  • Saverio Nucera,
  • Rosa Maria Bulotta,
  • Stefano Ruga,
  • Rosamaria Caminiti,
  • Maria Serra,
  • Roberto Bava,
  • Fabio Castagna,
  • Carmine Lupia,
  • Mariangela Marrelli and
  • Ernesto Palma
  • + 3 authors

8 November 2023

Plants are an untapped natural resource; their secondary metabolites take part in a variety of pharmacological activities, making them an essential ingredient in the synthesis of novel medications and the source of reserve resources in this process....

  • Article
  • Open Access
1 Citations
3,203 Views
13 Pages

siRNA Targeting PDE5A Partially Restores Vascular Damage Due to Type 1 Diabetes in a Streptozotocin-Induced Rat Model

  • Vanessa Giselle Garcia-Rubio,
  • Sandra Edith Cabrera-Becerra,
  • Sergio Adrian Ocampo-Ortega,
  • Citlali Margarita Blancas-Napoles,
  • Vivany Maydel Sierra-Sánchez,
  • Rodrigo Romero-Nava,
  • Rocío Alejandra Gutiérrez-Rojas,
  • Fengyang Huang,
  • Enrique Hong and
  • Santiago Villafaña

8 November 2023

Diabetes mellitus is a metabolic disease that can produce different alterations such as endothelial dysfunction, which is defined as a decrease in the vasodilator responses of the mechanisms involved such as the nitric oxide (NO) pathway. The overexp...

  • Communication
  • Open Access
3,258 Views
7 Pages

The Correlation of Two Different Real-Time PCR Devices for the Analysis of CYP2C19 Pharmacogenetic Results

  • Alba Alonso Llorente,
  • Josefa Salgado Garrido,
  • Oscar Teijido Hermida,
  • Fabricio González Andrade,
  • Alberto Valiente Martín,
  • Ana Fanlo Villacampa and
  • Jorge Vicente Romero

6 November 2023

CYP2C19 is a highly polymorphic gene responsible for the metabolism of commonly used drugs. CYP2C19*1, the wild-type allele, is associated with normal enzyme activity, whereas CYP2C19*2 and CYP2C19*17 lead to null and increased enzyme activity, respe...

  • Article
  • Open Access
4 Citations
6,222 Views
15 Pages

Phytochemical Standardization of an Extract Rich in Flavonoids from Flowers of Kalanchoe pinnata (Lam) Pers

  • Wilson Leonardo Villarreal Romero,
  • Jorge Eliecer Robles Camargo and
  • Geison Modesti Costa

2 November 2023

Kalanchoe pinnata is a species widely used in traditional medicine in Latin America and southern Africa. This species has been reported to have different activities, such as antioxidant, anti-inflammatory, and cytotoxic, the latter being related to i...

  • Article
  • Open Access
8 Citations
5,377 Views
17 Pages

18 October 2023

Plant-based therapies are widely utilized for treating diseases in approximately 80% of the global population, including Colombia’s Chocó Department. This study aimed to identify and evaluate plants with significant therapeutic value for...

  • Article
  • Open Access
6 Citations
4,248 Views
23 Pages

18 October 2023

Korean mistletoe (Viscum album var. coloratum) has been traditionally used as a remedy for cancer, diabetes, and hypertension. This study investigated the immuno-modulatory effects of Korean mistletoe water extract, specifically on MDA-MB-231 cells,...

  • Article
  • Open Access
2 Citations
3,645 Views
25 Pages

Neuropharmacological Activity of the Acetonic Extract of Malpighia mexicana A. Juss. and Its Phytochemical Profile

  • Dante Avilés-Montes,
  • David Osvaldo Salinas-Sánchez,
  • César Sotelo-Leyva,
  • Alejandro Zamilpa,
  • Franceli Itzel Batalla-Martinez,
  • Rodolfo Abarca-Vargas,
  • Juan Manuel Rivas-González,
  • Óscar Dorado,
  • Rodolfo Figueroa-Brito and
  • Manasés González-Cortazar
  • + 2 authors

10 October 2023

Mental and neurological disorders are conditions that affect thoughts, emotions, behavior, and relationships. Malpighia mexicana A. Juss. is a plant used in Mexican traditional medicine for the treatment of such disorders. This work aimed to investig...

  • Article
  • Open Access
3 Citations
3,708 Views
12 Pages

Hypoglycemic and Antihyperglycemic Potential of Flavonoid Fraction from Citrus sinensis (L.) Osbeck in Normoglycemic and Diabetic Rats

  • Jesús Alfredo Araujo-León,
  • Maira Rubi Segura-Campos,
  • Rolffy Ortiz-Andrade,
  • Priscila Vazquez-Garcia,
  • Daniela Carvajal-Sánchez,
  • Ángel Cabañas-Wuan,
  • Avel Adolfo González-Sánchez,
  • Jonatan Uuh-Narvaez,
  • Juan Carlos Sánchez-Salgado and
  • Zhelmy Martín-Quintal
  • + 1 author

27 September 2023

Diabetes is one of the most prevalent diseases worldwide, and the search for therapeutic alternatives in developing countries has been focused on natural products, primarily from plants. This study evaluated the antihyperglycemic and hypoglycemic act...

  • Article
  • Open Access
4 Citations
5,106 Views
16 Pages

Anti-Inflammatory Property Establishment of Fulvic Acid Transdermal Patch in Animal Model

  • Maria A. Konnova,
  • Alexander A. Volkov,
  • Anna G. Solovyeva,
  • Peter V. Peretyagin and
  • Nina B. Melnikova

26 September 2023

The formulation of the transdermal patch with fulvic acid (FA) on an emulsion basis using pluronic Kolliphor® p237 as a permeability enhancer was developed and studied for anti-inflammatory properties. FA was isolated from the peat in the Nizhny...

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Sci. Pharm. - ISSN 2218-0532