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Volume 83
Issue 2
10.3797/scipharm.1411-14
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Article

Synthesis and Anti-Platelet Activity of Thiosulfonate Derivatives Containing a Quinone Moiety

by
Khrystyna BOLIBRUKH
1,
Svyatoslav POLOVKOVYCH
1,*,
Omar KHOUMERI
2,
Tetyana HALENOVA
3,
Irina NIKOLAEVA
3,
Olexiy SAVCHUK
3,
Thierry TERME
2,
Patrice VANELLE
2,
Vira LUBENETS
1 and
Volodymyr NOVIKOV
1,*
1
Department of Technology of Biologically Active Substances, Pharmacy and Biotechnology, Lviv Polytechnic National University, Bandera Str. 12, 79013, Lviv, Ukraine.
2
Laboratoire de Pharmaco-Chimie Radicalaire, Institut de Chimie Radicalaire ICR, Faculté de Pharmacie, Aix-Marseille Univ, CNRS, UMR 7273, Bd J. Moulin 27, 13385, Marseille Cedex 05, France.
3
Educational and Scientific centre “Institute of Biology”, Taras Shevchenko National University of Kyiv, Volodymyrska Str. 64/13, 01601, Kyiv, Ukraine
*
Authors to whom correspondence should be addressed.
Sci. Pharm. 2015, 83(2), 221-231; https://doi.org/10.3797/scipharm.1411-14
Submission received: 26 November 2014 / Accepted: 24 February 2015 / Published: 24 February 2015
Versions Notes

Abstract

Thiosulfonate derivatives based on quinones were synthesized for studying “structure-activity relationship” compounds with an acylated and a free amino-group. Anti-platelet activity of the synthesized compounds was determined and the influence of substituents on the activity of the derivatives was assessed.
Keywords: Thiosulfonate; Quinone; Anti-platelet activity Thiosulfonate; Quinone; Anti-platelet activity

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MDPI and ACS Style

BOLIBRUKH, K.; POLOVKOVYCH, S.; KHOUMERI, O.; HALENOVA, T.; NIKOLAEVA, I.; SAVCHUK, O.; TERME, T.; VANELLE, P.; LUBENETS, V.; NOVIKOV, V. Synthesis and Anti-Platelet Activity of Thiosulfonate Derivatives Containing a Quinone Moiety. Sci. Pharm. 2015, 83, 221-231. https://doi.org/10.3797/scipharm.1411-14

AMA Style

BOLIBRUKH K, POLOVKOVYCH S, KHOUMERI O, HALENOVA T, NIKOLAEVA I, SAVCHUK O, TERME T, VANELLE P, LUBENETS V, NOVIKOV V. Synthesis and Anti-Platelet Activity of Thiosulfonate Derivatives Containing a Quinone Moiety. Scientia Pharmaceutica. 2015; 83(2):221-231. https://doi.org/10.3797/scipharm.1411-14

Chicago/Turabian Style

BOLIBRUKH, Khrystyna, Svyatoslav POLOVKOVYCH, Omar KHOUMERI, Tetyana HALENOVA, Irina NIKOLAEVA, Olexiy SAVCHUK, Thierry TERME, Patrice VANELLE, Vira LUBENETS, and Volodymyr NOVIKOV. 2015. "Synthesis and Anti-Platelet Activity of Thiosulfonate Derivatives Containing a Quinone Moiety" Scientia Pharmaceutica 83, no. 2: 221-231. https://doi.org/10.3797/scipharm.1411-14

APA Style

BOLIBRUKH, K., POLOVKOVYCH, S., KHOUMERI, O., HALENOVA, T., NIKOLAEVA, I., SAVCHUK, O., TERME, T., VANELLE, P., LUBENETS, V., & NOVIKOV, V. (2015). Synthesis and Anti-Platelet Activity of Thiosulfonate Derivatives Containing a Quinone Moiety. Scientia Pharmaceutica, 83(2), 221-231. https://doi.org/10.3797/scipharm.1411-14

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