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Sci. Pharm.
Volume 84
Issue 2
10.3797/scipharm.1505-16
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

Synthesis and Biological Activity of New [1,3]Thiazolo[4,5-d]pyridazin-4(5H)-ones

by
Anatoly DEMCHENKO
*,
Ludmila BOBKOVA
,
Oleh YADLOVSKIY
,
Tatiana BUCHTIAROVA
and
Sergey DEMCHENKO
Institute of Pharmacology and Toxicology, Eugene Pottier 14, 03057 Kiev, Ukraine
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2016, 84(2), 255-268; https://doi.org/10.3797/scipharm.1505-16
Submission received: 20 May 2015 / Accepted: 27 August 2015 / Published: 27 August 2015
Versions Notes

Abstract

A series of novel 2-(N-pyrrolidino, N-piperidino or N-morpholino)-7-phenyl(α-furoyl or α-thienyl)-[1,3]thiazolo[4,5-d]pyridazinones 10a-c, 14-16a,b was synthesized in 78-87% yields via the reaction of methyl 5-benzoyl(α-furoyl or α-thienyl)-2-aminosubstituted-thiazol-4-carboxylates 9a-c, 13a-e with hydrazine. These new compounds have been tested for their in vivo analgesic and anti-inflammatory activities. All compounds have been characterized by 1H-NMR, 13C-NMR spectroscopy, and liquid chromatography-mass spectrometry.
Keywords: [1,3]Thiazolo[4,5-d]pyridazinones; Anti-inflammatory activity; Anаlgеsic activity; In vivo tests;«Hot plate» model; «Acetic acid cramps» model [1,3]Thiazolo[4,5-d]pyridazinones; Anti-inflammatory activity; Anаlgеsic activity; In vivo tests;«Hot plate» model; «Acetic acid cramps» model

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MDPI and ACS Style

DEMCHENKO, A.; BOBKOVA, L.; YADLOVSKIY, O.; BUCHTIAROVA, T.; DEMCHENKO, S. Synthesis and Biological Activity of New [1,3]Thiazolo[4,5-d]pyridazin-4(5H)-ones. Sci. Pharm. 2016, 84, 255-268. https://doi.org/10.3797/scipharm.1505-16

AMA Style

DEMCHENKO A, BOBKOVA L, YADLOVSKIY O, BUCHTIAROVA T, DEMCHENKO S. Synthesis and Biological Activity of New [1,3]Thiazolo[4,5-d]pyridazin-4(5H)-ones. Scientia Pharmaceutica. 2016; 84(2):255-268. https://doi.org/10.3797/scipharm.1505-16

Chicago/Turabian Style

DEMCHENKO, Anatoly, Ludmila BOBKOVA, Oleh YADLOVSKIY, Tatiana BUCHTIAROVA, and Sergey DEMCHENKO. 2016. "Synthesis and Biological Activity of New [1,3]Thiazolo[4,5-d]pyridazin-4(5H)-ones" Scientia Pharmaceutica 84, no. 2: 255-268. https://doi.org/10.3797/scipharm.1505-16

APA Style

DEMCHENKO, A., BOBKOVA, L., YADLOVSKIY, O., BUCHTIAROVA, T., & DEMCHENKO, S. (2016). Synthesis and Biological Activity of New [1,3]Thiazolo[4,5-d]pyridazin-4(5H)-ones. Scientia Pharmaceutica, 84(2), 255-268. https://doi.org/10.3797/scipharm.1505-16

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