Next Article in Journal
Synthesis and Characterization of Compounds Related to Lisinopril
Previous Article in Journal
Synthesis and Anti-Platelet Activity of Thiosulfonate Derivatives Containing a Quinone Moiety
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Sci. Pharm.
Volume 83
Issue 2
10.3797/scipharm.1409-15
scipharm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

An Alternative Approach to Isoganciclovir: A Prominent Impurity in the Antiviral Drug Ganciclovir

by
Dhanraj T. S. S. SUNDARAM
1,2,*,
Anand G. KAMAT
1,
Koilpillai Joseph PRABAHAR
1,
Peruri Badarinadh GUPTA
1,
Battula VENKATESWARA RAO
2 and
Sanasi PAUL DOUGLAS
2
1
Chemical Research and Development, APL Research Centre-II, Aurobindo Pharma Ltd., Survey No. 71 & 72, Indrakaran (V), Medak District-502 329, Andhra Pradesh, India.
2
Department of Engineering Chemistry, Andhra University College of Engineering (A), Andhra University, Visakhapatnam-530003, Andhra Pradesh, India.
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2015, 83(2), 233-241; https://doi.org/10.3797/scipharm.1409-15
Submission received: 27 September 2014 / Accepted: 11 November 2014 / Published: 11 November 2014
Versions Notes

Abstract

A simple and efficient process for the preparation of (±)-9-[(2,3-dihydroxy-propoxy)methyl]guanine (isoganciclovir) is described. The synthesis features the preparation of a kinetically and thermodynamically controlled acyclic side chain using masked glycerol and methoxymethyl acetate. The unwanted regioisomers were separated through selective crystallization, which upon deprotection yielded isoganciclovir in good yield. The present work explains the preparation of the acyclic side chain in a simple manner without the aid of any preparative column purification or separation technique.
Keywords: Anti-herpes; Cytomegalovirus; Methoxymethyl acetate; Valganciclovir hydrochloride Anti-herpes; Cytomegalovirus; Methoxymethyl acetate; Valganciclovir hydrochloride

Share and Cite

MDPI and ACS Style

SUNDARAM, D.T.S.S.; KAMAT, A.G.; PRABAHAR, K.J.; GUPTA, P.B.; VENKATESWARA RAO, B.; PAUL DOUGLAS, S. An Alternative Approach to Isoganciclovir: A Prominent Impurity in the Antiviral Drug Ganciclovir. Sci. Pharm. 2015, 83, 233-241. https://doi.org/10.3797/scipharm.1409-15

AMA Style

SUNDARAM DTSS, KAMAT AG, PRABAHAR KJ, GUPTA PB, VENKATESWARA RAO B, PAUL DOUGLAS S. An Alternative Approach to Isoganciclovir: A Prominent Impurity in the Antiviral Drug Ganciclovir. Scientia Pharmaceutica. 2015; 83(2):233-241. https://doi.org/10.3797/scipharm.1409-15

Chicago/Turabian Style

SUNDARAM, Dhanraj T. S. S., Anand G. KAMAT, Koilpillai Joseph PRABAHAR, Peruri Badarinadh GUPTA, Battula VENKATESWARA RAO, and Sanasi PAUL DOUGLAS. 2015. "An Alternative Approach to Isoganciclovir: A Prominent Impurity in the Antiviral Drug Ganciclovir" Scientia Pharmaceutica 83, no. 2: 233-241. https://doi.org/10.3797/scipharm.1409-15

APA Style

SUNDARAM, D. T. S. S., KAMAT, A. G., PRABAHAR, K. J., GUPTA, P. B., VENKATESWARA RAO, B., & PAUL DOUGLAS, S. (2015). An Alternative Approach to Isoganciclovir: A Prominent Impurity in the Antiviral Drug Ganciclovir. Scientia Pharmaceutica, 83(2), 233-241. https://doi.org/10.3797/scipharm.1409-15

Article Metrics

Back to TopTop