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Sci. Pharm. 2013, 81(3), 651-662; https://doi.org/10.3797/scipharm.1212-21 (registering DOI)
Synthesis and Characterization of Potential Dimers of Gatifloxacin – an Antibacterial Drug
Chemical Research and Development Department, Aurobindo Pharma Ltd, Survey No: 71&72, Indrakaran (V), Sangareddy (M), Medak Dist., Hyderabad – 502 329, Andhra Pradesh, India
Department of Engineering Chemistry, A. U. College of Engineering (A), Andhra University, Visakhapatnam – 530 003, Andhra Pradesh, India
Author to whom correspondence should be addressed.
Received: 20 December 2012 / Accepted: 18 February 2013 / Published: 18 February 2013
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Abstract Gatifloxacin is an antibacterial agent belonging to the fourth-generation fluoroquinolone family. Four piperazine-linked fluoroquinolone dimers of Gatifloxacin were observed during the laboratory process for Gatifloxacin and they were identified. The present work describes the origin, synthesis, characterization, and control of these dimers along with the synthesis of Despropylene Gatifloxacin (metabolite).
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GARAGA, S.; REDDY, A.V.R.; PRABAHAR, K.J.; KORUPOLU, R.B.; SANASI, P.D. Synthesis and Characterization of Potential Dimers of Gatifloxacin – an Antibacterial Drug. Sci. Pharm. 2013, 81, 651-662.
GARAGA S, REDDY AVR, PRABAHAR KJ, KORUPOLU RB, SANASI PD. Synthesis and Characterization of Potential Dimers of Gatifloxacin – an Antibacterial Drug. Scientia Pharmaceutica. 2013; 81(3):651-662.
GARAGA, Srinivas; REDDY, Ambati V.R.; PRABAHAR, Koilpillai J.; KORUPOLU, Raghu B.; SANASI, Paul D. 2013. "Synthesis and Characterization of Potential Dimers of Gatifloxacin – an Antibacterial Drug." Sci. Pharm. 81, no. 3: 651-662.
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