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Volume 81
Issue 3
10.3797/scipharm.1212-21
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Article

Synthesis and Characterization of Potential Dimers of Gatifloxacin – an Antibacterial Drug

by
Srinivas GARAGA
1,2,
Ambati V. RAGHAVA REDDY
1,
Koilpillai Joseph PRABAHAR
1,
Raghu Babu KORUPOLU
2 and
Paul Douglas SANASI
2,*
1
Chemical Research and Development Department, Aurobindo Pharma Ltd, Survey No: 71&72, Indrakaran (V), Sangareddy (M), Medak Dist., Hyderabad – 502 329, Andhra Pradesh, India
2
Department of Engineering Chemistry, A. U. College of Engineering (A), Andhra University, Visakhapatnam – 530 003, Andhra Pradesh, India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2013, 81(3), 651-662; https://doi.org/10.3797/scipharm.1212-21
Submission received: 20 December 2012 / Accepted: 18 February 2013 / Published: 18 February 2013
Versions Notes

Abstract

Gatifloxacin is an antibacterial agent belonging to the fourth-generation fluoroquinolone family. Four piperazine-linked fluoroquinolone dimers of Gatifloxacin were observed during the laboratory process for Gatifloxacin and they were identified. The present work describes the origin, synthesis, characterization, and control of these dimers along with the synthesis of Despropylene Gatifloxacin (metabolite).
Keywords: Gatifloxacin; Piperazine dimers; Synthesis; Characterization Gatifloxacin; Piperazine dimers; Synthesis; Characterization

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MDPI and ACS Style

GARAGA, S.; REDDY, A.V.R.; PRABAHAR, K.J.; KORUPOLU, R.B.; SANASI, P.D. Synthesis and Characterization of Potential Dimers of Gatifloxacin – an Antibacterial Drug. Sci. Pharm. 2013, 81, 651-662. https://doi.org/10.3797/scipharm.1212-21

AMA Style

GARAGA S, REDDY AVR, PRABAHAR KJ, KORUPOLU RB, SANASI PD. Synthesis and Characterization of Potential Dimers of Gatifloxacin – an Antibacterial Drug. Scientia Pharmaceutica. 2013; 81(3):651-662. https://doi.org/10.3797/scipharm.1212-21

Chicago/Turabian Style

GARAGA, Srinivas, Ambati V. RAGHAVA REDDY, Koilpillai Joseph PRABAHAR, Raghu Babu KORUPOLU, and Paul Douglas SANASI. 2013. "Synthesis and Characterization of Potential Dimers of Gatifloxacin – an Antibacterial Drug" Scientia Pharmaceutica 81, no. 3: 651-662. https://doi.org/10.3797/scipharm.1212-21

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