Synthesis and Characterization of Potential Dimers of Gatifloxacin – an Antibacterial Drug

Srinivas GARAGA; Ambati V. RAGHAVA REDDY; Koilpillai Joseph PRABAHAR; Raghu Babu KORUPOLU; Paul Douglas SANASI

doi:10.3797/scipharm.1212-21

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Article

18 February 2013

Synthesis and Characterization of Potential Dimers of Gatifloxacin – an Antibacterial Drug

and

Chemical Research and Development Department, Aurobindo Pharma Ltd, Survey No: 71&72, Indrakaran (V), Sangareddy (M), Medak Dist., Hyderabad – 502 329, Andhra Pradesh, India

Department of Engineering Chemistry, A. U. College of Engineering (A), Andhra University, Visakhapatnam – 530 003, Andhra Pradesh, India

Author to whom correspondence should be addressed.

Sci. Pharm.2013, 81(3), 651-662;https://doi.org/10.3797/scipharm.1212-21

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Abstract

Gatifloxacin is an antibacterial agent belonging to the fourth-generation fluoroquinolone family. Four piperazine-linked fluoroquinolone dimers of Gatifloxacin were observed during the laboratory process for Gatifloxacin and they were identified. The present work describes the origin, synthesis, characterization, and control of these dimers along with the synthesis of Despropylene Gatifloxacin (metabolite).

Keywords:

Gatifloxacin; Piperazine dimers; Synthesis; Characterization

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