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Sci. Pharm.
Volume 81
Issue 3
10.3797/scipharm.1304-17
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

Synthesis and Biological Evaluation of Novel Alkyl-Imidazolyl Carbinols and their Esters: Potent Antimycotics

by
Jürgen KRAUSS
,
Carina GRATZL
,
Verena STURM
,
Christoph MÜLLER
,
Verena STAUDACHER
,
Christoph Q. SCHMIDT
and
Franz BRACHER
*
Department of Pharmacy – Center for Drug Research, Ludwig-Maximilians University, Butenandtstr. 5–13, 81377 Munich, Germany
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2013, 81(3), 641-650; https://doi.org/10.3797/scipharm.1304-17
Submission received: 17 April 2013 / Accepted: 21 August 2013 / Published: 21 August 2013
Versions Notes

Abstract

A novel series of imidazol-5-yl carbinols and their 4-chlorobenzoyl esters has been synthesized by the Grignard reaction and subsequent esterification. These compounds were screened for their antimicrobial activities in an agar diffusion assay. The compounds with C10 to C12-alkyl side chains displayed significant antimycotic activity.
Keywords: Grignard reaction; Ergosterol biosynthesis; Sterol biosynthesis inhibitors; Antimycotics Grignard reaction; Ergosterol biosynthesis; Sterol biosynthesis inhibitors; Antimycotics

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MDPI and ACS Style

KRAUSS, J.; GRATZL, C.; STURM, V.; MÜLLER, C.; STAUDACHER, V.; SCHMIDT, C.Q.; BRACHER, F. Synthesis and Biological Evaluation of Novel Alkyl-Imidazolyl Carbinols and their Esters: Potent Antimycotics. Sci. Pharm. 2013, 81, 641-650. https://doi.org/10.3797/scipharm.1304-17

AMA Style

KRAUSS J, GRATZL C, STURM V, MÜLLER C, STAUDACHER V, SCHMIDT CQ, BRACHER F. Synthesis and Biological Evaluation of Novel Alkyl-Imidazolyl Carbinols and their Esters: Potent Antimycotics. Scientia Pharmaceutica. 2013; 81(3):641-650. https://doi.org/10.3797/scipharm.1304-17

Chicago/Turabian Style

KRAUSS, Jürgen, Carina GRATZL, Verena STURM, Christoph MÜLLER, Verena STAUDACHER, Christoph Q. SCHMIDT, and Franz BRACHER. 2013. "Synthesis and Biological Evaluation of Novel Alkyl-Imidazolyl Carbinols and their Esters: Potent Antimycotics" Scientia Pharmaceutica 81, no. 3: 641-650. https://doi.org/10.3797/scipharm.1304-17

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