Synthesis and Biological Evaluation of Novel Alkyl-Imidazolyl Carbinols and their Esters: Potent Antimycotics

Jürgen KRAUSS; Carina GRATZL; Verena STURM; Christoph MÜLLER; Verena STAUDACHER; Christoph Q. SCHMIDT; Franz BRACHER

doi:10.3797/scipharm.1304-17

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Article

21 August 2013

Synthesis and Biological Evaluation of Novel Alkyl-Imidazolyl Carbinols and their Esters: Potent Antimycotics

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Department of Pharmacy – Center for Drug Research, Ludwig-Maximilians University, Butenandtstr. 5–13, 81377 Munich, Germany

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Sci. Pharm.2013, 81(3), 641-650;https://doi.org/10.3797/scipharm.1304-17

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Abstract

A novel series of imidazol-5-yl carbinols and their 4-chlorobenzoyl esters has been synthesized by the Grignard reaction and subsequent esterification. These compounds were screened for their antimicrobial activities in an agar diffusion assay. The compounds with C₁₀ to C₁₂-alkyl side chains displayed significant antimycotic activity.

Keywords:

Grignard reaction; Ergosterol biosynthesis; Sterol biosynthesis inhibitors; Antimycotics

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