Synthesis of 1,2,3-Triazole Derivatives and Evaluation of their Anticancer Activity

Nazariy POKHODYLO; Olga SHYYKA; Vasyl MATIYCHUK

doi:10.3797/scipharm.1302-04

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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).

Article

14 April 2013

Synthesis of 1,2,3-Triazole Derivatives and Evaluation of their Anticancer Activity

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Ivan Franko National University of Lviv, Kyryla & Mefodiya Str., 6, 79005 Lviv, Ukraine

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Sci. Pharm.2013, 81(3), 663-676;https://doi.org/10.3797/scipharm.1302-04

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Abstract

Anticancer screening of several 1,2,3-triazoles with heterocyclic fragments has been performed. The 1,2,3-triazole derivatives were synthesized from available starting materials according to convenient synthetic procedures. The antitumor activity of the synthesized compounds was tested in vitro by the National Cancer Institute in NCI60 cell lines. It was observed that some compounds showed slight anticancer activity. One of them possessed a moderate activity against melanoma, colon, and breast cancer. Standard COMPARE analysis was performed at the GI₅₀level.

Keywords:

1,2,3-Triazoles; Pfitzinger reaction; Anticancer activity; COMPARE analysis

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