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Sci. Pharm.
Volume 78
Issue 2
10.3797/scipharm.0912-16
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Article

Synthesis and Antimicrobial Activity of 3-(1,3,4-Oxadiazol-2-yl)quinazolin-4(3H)-ones

by
Navin B. PATEL
* and
Jaymin C. PATEL
Department of Chemistry, Veer Narmad South Gujarat University, Surat 395007, Gujarat, India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2010, 78(2), 171-194; https://doi.org/10.3797/scipharm.0912-16
Submission received: 17 December 2009 / Accepted: 26 April 2010 / Published: 26 April 2010
Versions Notes

Abstract

In attempt to find new pharmacologically active molecules, we report here the synthesis and in vitro antimicrobial activity of various 3-(1,3,4-oxadiazol-2-yl)- quinazolin-4(3H)-ones. The antimicrobial activity of title compounds were examined against two gram positive bacteria (S. aureus, S. pyogenes), two gram negative bacteria (E. coli, P. aeruginosa) and three fungi (C. albicans, A. niger, A. clavatus) using the broth microdilution method. Some derivatives bearing a bromo or iodo group exhibited very good antimicrobial activity.
Keywords: Antimicrobial activity; 1,3,4-Oxadiazole; Quinazolin-4(3H)-one Antimicrobial activity; 1,3,4-Oxadiazole; Quinazolin-4(3H)-one

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MDPI and ACS Style

PATEL, N.B.; PATEL, J.C. Synthesis and Antimicrobial Activity of 3-(1,3,4-Oxadiazol-2-yl)quinazolin-4(3H)-ones. Sci. Pharm. 2010, 78, 171-194. https://doi.org/10.3797/scipharm.0912-16

AMA Style

PATEL NB, PATEL JC. Synthesis and Antimicrobial Activity of 3-(1,3,4-Oxadiazol-2-yl)quinazolin-4(3H)-ones. Scientia Pharmaceutica. 2010; 78(2):171-194. https://doi.org/10.3797/scipharm.0912-16

Chicago/Turabian Style

PATEL, Navin B., and Jaymin C. PATEL. 2010. "Synthesis and Antimicrobial Activity of 3-(1,3,4-Oxadiazol-2-yl)quinazolin-4(3H)-ones" Scientia Pharmaceutica 78, no. 2: 171-194. https://doi.org/10.3797/scipharm.0912-16

APA Style

PATEL, N. B., & PATEL, J. C. (2010). Synthesis and Antimicrobial Activity of 3-(1,3,4-Oxadiazol-2-yl)quinazolin-4(3H)-ones. Scientia Pharmaceutica, 78(2), 171-194. https://doi.org/10.3797/scipharm.0912-16

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