Synthesis and Antimicrobial Activity of 3-(1,3,4-Oxadiazol-2-yl)quinazolin-4(3H)-ones

Navin B. PATEL; Jaymin C. PATEL

doi:10.3797/scipharm.0912-16

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Article

26 April 2010

Synthesis and Antimicrobial Activity of 3-(1,3,4-Oxadiazol-2-yl)quinazolin-4(3H)-ones

and

Department of Chemistry, Veer Narmad South Gujarat University, Surat 395007, Gujarat, India

Author to whom correspondence should be addressed.

Sci. Pharm.2010, 78(2), 171-194;https://doi.org/10.3797/scipharm.0912-16

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Abstract

In attempt to find new pharmacologically active molecules, we report here the synthesis and in vitro antimicrobial activity of various 3-(1,3,4-oxadiazol-2-yl)- quinazolin-4(3H)-ones. The antimicrobial activity of title compounds were examined against two gram positive bacteria (S. aureus, S. pyogenes), two gram negative bacteria (E. coli, P. aeruginosa) and three fungi (C. albicans, A. niger, A. clavatus) using the broth microdilution method. Some derivatives bearing a bromo or iodo group exhibited very good antimicrobial activity.

Keywords:

Antimicrobial activity; 1,3,4-Oxadiazole; Quinazolin-4(3H)-one

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