Indirubine-3-Monoxime Inhibits PDGF-Mediated Vascular Smooth Muscle Cell Migration

I. SROKA; E. H. HEISS; C. CZALOUN; V. M. DIRSCH

doi:10.3797/scipharm.oephg.21.PO-45

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Abstract

16 April 2009

Indirubine-3-Monoxime Inhibits PDGF-Mediated Vascular Smooth Muscle Cell Migration

and

Department of Pharmacognosy, University of Vienna, Althanstr. 14, 1090, Vienna, Austria

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Sci. Pharm.2009, 77(7), 244;https://doi.org/10.3797/scipharm.oephg.21.PO-45

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Abstract

During the pathology of atherosclerosis and restenosis, hyperproliferation and migration of vascular smooth muscle cells (VSMC) contribute to lumen loss of the vessel and neointima formation [1]. Drugs interfering with both, proliferation and migration of VSMC are therefore promising candidates for the treatment of vasculoproliferative diseases.

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