Antispasmodic Activity of Semi-Synthetic Secoisopimarane Derivatives

ROMUSSI, A.; PIERETTI, S.; COLUCCI, M.; MASTRIOTA, M.; DE TOMMASI, N.; Mascolo, N.; BRUNO, O.; BISIO, A.

doi:10.3797/scipharm.oephg.21.PO-16

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Abstract

16 April 2009

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Antispasmodic Activity of Semi-Synthetic Secoisopimarane Derivatives

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Dipartimento di Scienze Farmaceutiche, Università di Genova, Viale Benedetto XV, 16131, Genova, Italia

Department of Drug Research and Evaluation, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma, Italia

Dipartimento di Scienze Farmaceutiche,Università di Salerno, Via Ponte Don Melillo, 84084, Salerno, Italia

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Dipartimento di Farmacologia Sperimentale, Università di Napoli ‘Federico II’, via D. Montesano 49, 80131 Napoli, Italia

Sci. Pharm.2009, 77(7), 215;https://doi.org/10.3797/scipharm.oephg.21.PO-16

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Abstract

The effects on ileal contraction of some synthetic derivatives of the bioactive [1–3] 3,4-secoisopimara-4(18),7,15-trien-3-oic acid (1) isolated from S. cinnabarina are reported.

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