Enantioseparation with Capillary Electrophoresis (CE) as Evidence of Chirality Retention during Kolbe Electrolysis of Amino Acids

DÖRNER, B.; LACHMANN, B.; KRATZEL, M.

doi:10.3797/scipharm.oephg.21.PO-09

Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).

Abstract

16 April 2009

1 Page

Enantioseparation with Capillary Electrophoresis (CE) as Evidence of Chirality Retention during Kolbe Electrolysis of Amino Acids

and

Department of Medicinal Chemistry, University of Vienna, Althanstraße 14, 1090, Vienna, Austria

Author to whom correspondence should be addressed.

Sci. Pharm.2009, 77(7), 208;https://doi.org/10.3797/scipharm.oephg.21.PO-09

Version Notes

Order Reprints

Abstract

The radical Kolbe electrolysis can be applied to synthesize non-proteinogenic amino acids starting from ʟ-glutamic acid (or L-aspartic acid, respectively). Using suitable protecting groups for both amino and carboxy functionalities, the retention of chirality at the α-carbon atom can be expected.

Article Metrics

Citations

Article Access Statistics

Journal Statistics

Multiple requests from the same IP address are counted as one view.

SIBAR Descriptors and Support Vector Machine for ABCB1 Substrate Prediction

Kolbe Electrolysis as a Novel Way of Generating Non-Proteinogenic Amino Acids