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Enantioseparation with Capillary Electrophoresis (CE) as Evidence of Chirality Retention during Kolbe Electrolysis of Amino Acids
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Sci. Pharm. 2009, 77(Posters (PO)), 209; (registering DOI)

Kolbe Electrolysis as a Novel Way of Generating Non-Proteinogenic Amino Acids

Department of Medicinal Chemistry, University of Vienna, Althanstraße 14, 1090, Vienna, Austria
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
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By using Kolbe electrolysis [1], an anodic oxidation, carboxylic acids are able to form dimers through precent decarboxylation and generation of radicals. The scope of the Kolbe reaction can be considerably enhanced by cross-reaction of two different carboxylic acids. L-glutamic acid (Glu), which is blocked at the α-carboxyl and the amino group by protective groups, opens a new way for the synthesis of non-proteinogenic amino acids with defined stereochemistry. As examples Z-L-norleucine and amino acids containing a second amino group at its side chain were synthesized.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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DÖRNER, B.; KRATZEL, M. Kolbe Electrolysis as a Novel Way of Generating Non-Proteinogenic Amino Acids. Sci. Pharm. 2009, 77, 209.

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