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Enantioseparation with Capillary Electrophoresis (CE) as Evidence of Chirality Retention during Kolbe Electrolysis of Amino Acids
 
 
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Sci. Pharm.
Volume 77
Issue 7
10.3797/scipharm.oephg.21.PO-10
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Abstract

Kolbe Electrolysis as a Novel Way of Generating Non-Proteinogenic Amino Acids

by
B. DÖRNER
* and
M. KRATZEL
Department of Medicinal Chemistry, University of Vienna, Althanstraße 14, 1090, Vienna, Austria
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2009, 77(7), 209; https://doi.org/10.3797/scipharm.oephg.21.PO-10
Submission received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
Versions Notes

Abstract

By using Kolbe electrolysis [1], an anodic oxidation, carboxylic acids are able to form dimers through precent decarboxylation and generation of radicals. The scope of the Kolbe reaction can be considerably enhanced by cross-reaction of two different carboxylic acids. L-glutamic acid (Glu), which is blocked at the α-carboxyl and the amino group by protective groups, opens a new way for the synthesis of non-proteinogenic amino acids with defined stereochemistry. As examples Z-L-norleucine and amino acids containing a second amino group at its side chain were synthesized.

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MDPI and ACS Style

DÖRNER, B.; KRATZEL, M. Kolbe Electrolysis as a Novel Way of Generating Non-Proteinogenic Amino Acids. Sci. Pharm. 2009, 77, 209. https://doi.org/10.3797/scipharm.oephg.21.PO-10

AMA Style

DÖRNER B, KRATZEL M. Kolbe Electrolysis as a Novel Way of Generating Non-Proteinogenic Amino Acids. Scientia Pharmaceutica. 2009; 77(Posters (PO)):209. https://doi.org/10.3797/scipharm.oephg.21.PO-10

Chicago/Turabian Style

DÖRNER, B., and M. KRATZEL. 2009. "Kolbe Electrolysis as a Novel Way of Generating Non-Proteinogenic Amino Acids" Scientia Pharmaceutica 77, Posters (PO): 209. https://doi.org/10.3797/scipharm.oephg.21.PO-10

APA Style

DÖRNER, B., & KRATZEL, M. (2009). Kolbe Electrolysis as a Novel Way of Generating Non-Proteinogenic Amino Acids. Scientia Pharmaceutica, 77(Posters (PO)), 209. https://doi.org/10.3797/scipharm.oephg.21.PO-10

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