Validation of Fluorimetric Assay of Histone Deacetylase for Inhibitors from Plant Origin

KRASTEVA, S. M.; KRENN, L.

doi:10.3797/scipharm.oephg.21.SL-13

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Abstract

16 April 2009

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Validation of Fluorimetric Assay of Histone Deacetylase for Inhibitors from Plant Origin

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Department of Pharmacognosy, University Vienna, Althanstraße 14, 1090, Vienna, Austria

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Sci. Pharm.2009, 77(6), 180;https://doi.org/10.3797/scipharm.oephg.21.SL-13

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Abstract

Histone deacetylase inhibitors (HDACi) have received high interest as anti-cancer agents recently. HDACi may influence tumor growth by an inhibition of angiogenesis as well as by increasing tumor cell immunogenicity [1]. In many clinical trials the effect of several HDACi on different tumors are studied at the moment [2].

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