Validation of Fluorimetric Assay of Histone Deacetylase for Inhibitors from Plant Origin

S. M. KRASTEVA; L. KRENN

doi:10.3797/scipharm.oephg.21.SL-13

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Abstract

16 April 2009

Validation of Fluorimetric Assay of Histone Deacetylase for Inhibitors from Plant Origin

and

Department of Pharmacognosy, University Vienna, Althanstraße 14, 1090, Vienna, Austria

Author to whom correspondence should be addressed.

Sci. Pharm.2009, 77(6), 180;https://doi.org/10.3797/scipharm.oephg.21.SL-13

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Abstract

Histone deacetylase inhibitors (HDACi) have received high interest as anti-cancer agents recently. HDACi may influence tumor growth by an inhibition of angiogenesis as well as by increasing tumor cell immunogenicity [1]. In many clinical trials the effect of several HDACi on different tumors are studied at the moment [2].

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