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Sci. Pharm.
Volume 77
Issue 6
10.3797/scipharm.oephg.21.SL-12
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Abstract

Pluronic® F-68 Enhances the Nanoparticle-Cell Interaction

by
V. KERLETA
1,*,
I. ANDRLIK
1,
M. SCHNEIDER
2,
T. FRANKE
2,
M. WIRTH
1 and
F. GABOR
1
1
Dept of Pharm. Technology a. Biopharmaceutics, Univ. of Vienna, Althanstr. 14, A-1090 Vienna, Austria
2
Institute of Physics, Univ. of Augsburg, Universitätsstr. 1, D-86135 Augsburg, Germany
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2009, 77(6), 179; https://doi.org/10.3797/scipharm.oephg.21.SL-12
Submission received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
Versions Notes

Abstract

Nowadays, the various surfactants find wide application in pharmaceutical industry. The nanoparticle preparation process by emulsion techniques essentially requires a surfactant, most commonly Pluronic® F-68 [1]. This non-ionic tenside influences cell physiology and was tested in clinical trial for the treatment of sickle cell disease [2] and myocardial infarction [3]. Out of these reasons, even residual tenside in nanoparticle preparations might influence the cells as well as their interaction with the colloidal carriers. At this, Caco-2 single cells were incubated with fluorescent polystyrene nanoparticles, in presence of increasing amounts of Pluronic® F-68 and cell-associated nanoparticles were detected by flow cytometry. Independent from incubation temperature, the cell-associated fraction of nanoparticles concurrently increased with the tenside concentration. Ongoing from micropipette aspiration experiments this effect could be attributed to an increase of membrane stiffness of Caco-2 cells in presence of Pluronic® F-68. Furthermore, the toxicity assay revealed that viability of the cells remained unaffected at any concentration of Pluronic® F-68.

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MDPI and ACS Style

KERLETA, V.; ANDRLIK, I.; SCHNEIDER, M.; FRANKE, T.; WIRTH, M.; GABOR, F. Pluronic® F-68 Enhances the Nanoparticle-Cell Interaction. Sci. Pharm. 2009, 77, 179. https://doi.org/10.3797/scipharm.oephg.21.SL-12

AMA Style

KERLETA V, ANDRLIK I, SCHNEIDER M, FRANKE T, WIRTH M, GABOR F. Pluronic® F-68 Enhances the Nanoparticle-Cell Interaction. Scientia Pharmaceutica. 2009; 77(Short Lectures (SL)):179. https://doi.org/10.3797/scipharm.oephg.21.SL-12

Chicago/Turabian Style

KERLETA, V., I. ANDRLIK, M. SCHNEIDER, T. FRANKE, M. WIRTH, and F. GABOR. 2009. "Pluronic® F-68 Enhances the Nanoparticle-Cell Interaction" Scientia Pharmaceutica 77, Short Lectures (SL): 179. https://doi.org/10.3797/scipharm.oephg.21.SL-12

APA Style

KERLETA, V., ANDRLIK, I., SCHNEIDER, M., FRANKE, T., WIRTH, M., & GABOR, F. (2009). Pluronic® F-68 Enhances the Nanoparticle-Cell Interaction. Scientia Pharmaceutica, 77(Short Lectures (SL)), 179. https://doi.org/10.3797/scipharm.oephg.21.SL-12

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