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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).

Sci. Pharm., Volume 72, Issue 1 (March 2004) – 9 articles

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248 KiB  
Erratum
Erratum to "Tropane alkaloids from a Brazilian bark traded as 'Catuaba'*" [Scientia Pharmaceutica 71,113-119 (2003)]
by Sabine Glasl, Armin Presser, Ingrid Werner, Ernst Haslinger and Johann Jurenitsch
Sci. Pharm. 2004, 72(1), 97; https://doi.org/10.3797/scipharm.aut-04-09 - 19 Mar 2004
Cited by 1 | Viewed by 1136
Abstract
The authors regret that the chemical structure of compound 2 was indicated incorrectly as catuabine C. [...] Full article
3490 KiB  
Article
Medicinal used plants from lndia: analysis of the essential oil of air-dried Biophvtum sensitivum (L.) DC.
by Leopold Jirovetz, Gerhard Buchbauer, Andrea Wobus, Mohamed P. Shafi and Beena Jose
Sci. Pharm. 2004, 72(1), 87-96; https://doi.org/10.3797/scipharm.aut-04-08 - 17 Mar 2004
Cited by 16 | Viewed by 1530
Abstract
The essential oil of the air-dried plant Biophytum sensitivum (L.) DC. (Oxalidaceae) from Southern lndia was investigated by gas chromatographic-spectroscopic (GC-FID and GC-MS) and olfactoric methods to identify compounds responsible for the characteristic odor as well as partly for the folk medicinal use [...] Read more.
The essential oil of the air-dried plant Biophytum sensitivum (L.) DC. (Oxalidaceae) from Southern lndia was investigated by gas chromatographic-spectroscopic (GC-FID and GC-MS) and olfactoric methods to identify compounds responsible for the characteristic odor as well as partly for the folk medicinal use of this plant. Especially benzene derivatives, such as 1,4-dimethoxy benzene (24.9%), 1,2-dimethoxy benzene (10.6%) and 2-methoxy-4-methyl phenol (3.5%), the monoterpenes (Z)-linalool oxide (8.1%), (E)-linalool oxide (5.2%) and linalyl acetate (3.4%) as well as l-octen-3-ol (9.5%) and isophorone (3.1%) were found to be main constituents (concentrations higher than 3%, calculated as relative %-peak area of GC-FID analysis using an apolar column) of this essential oil, with totally 69 compounds identified. In addition, the odor impression of the sample is described and the possible biological activity of single volatiles discussed. Full article
3950 KiB  
Article
Spectrophotometric Determination of Aciclovir, Cefepirne Hydrochloride, Etamsylate and Metoclopramide Hydrochloride Usina 1,10 Phenanttrroline—Fe(lll) Reaqent
by Marwa S. Elazazy, Abdalla Shalaby, M. N. Elbolkiny and Hawa M. Khalil
Sci. Pharm. 2004, 72(1), 73-86; https://doi.org/10.3797/scipharm.aut-04-07 - 15 Mar 2004
Cited by 8 | Viewed by 1232
Abstract
A simple, rapid, sensitive and accurate method for the determination of aciclovir, cefepime HCI, etamsylate and metoclopramide HCI in pure form and in pharmaceutical formulations is developed.The method is based on the fomabon of tris(o-phenanthroline) iron(ll) complex (Ferroin) upon the reaction of the [...] Read more.
A simple, rapid, sensitive and accurate method for the determination of aciclovir, cefepime HCI, etamsylate and metoclopramide HCI in pure form and in pharmaceutical formulations is developed.The method is based on the fomabon of tris(o-phenanthroline) iron(ll) complex (Ferroin) upon the reaction of the ated drugs wrth iron(lll )-o- phenanthroline mixture. The ferroin complex is colorimetncally measured at λmax 510 nm against a reagent blank. 0ptimization of the experimental conditions is described. Beer's law is obeyed in the concentration range from 0.25–30 µg ml−1 with molar absorpitivities (ε) ranging from 4.796 x 103–9.51 2 x 104 L.mol−1.cm−1 and Sandell sensitivities (S) of 2.129 x 10−3–34.5 x 10−3 µg cm−2. The developed method is applied successfully for the determination of the cited drugs in pure forms and in the corresponding pharmaceutical formulations without any interferences from common excipients. Full article
6577 KiB  
Article
Colourimetric and atomic absorption spectrometric determination of some f luoroquinolone derivatives
by Hesham Salem
Sci. Pharm. 2004, 72(1), 51-71; https://doi.org/10.3797/scipharm.aut-04-06 - 13 Mar 2004
Cited by 5 | Viewed by 1126
Abstract
Three simple, accurate, sensitive and selective procedures for the determination of ten fluoroquinolones (amifloxacin, ciprofloxacin hydrochloride, difloxacin hydrochloride, enoxacin, enrofloxacin, lomefloxacin hydrochloride, lovefloxacin, norfloxacin, ofloxacin and pefloxacin mesylate) were described. Procedures I and II are based on the formation of ion-pair complexes between [...] Read more.
Three simple, accurate, sensitive and selective procedures for the determination of ten fluoroquinolones (amifloxacin, ciprofloxacin hydrochloride, difloxacin hydrochloride, enoxacin, enrofloxacin, lomefloxacin hydrochloride, lovefloxacin, norfloxacin, ofloxacin and pefloxacin mesylate) were described. Procedures I and II are based on the formation of ion-pair complexes between the drugs and ammonium reineckate reagent in an acidic medium at 25 ±2°C and the formed precipitates are quantitatively determined either colourimetrically (procedure I) or by atomic absorption spectrometrically (procedure II). Procedure I is based on dissolving the formed precipitate with acetone, the volume was completed quantitatively and the absorbance of the solution was measured at 527 nm against pure solvent blank. The formed precipitates on the atomic absorption spectrometric procedure (procedure II) are quantitatively determined either directly or indirectly through the chromium precipitate formed or the residual un-reacted chromium in the filtrate at 358.6 nm and the optimum conditions for precipitation have been carefully studied. Procedure Ill is based on the reaction of the studied drugs with 2,2-diphenyl-1-picrylhydrazyl reagent (DPPH). The latter is employed to abstract a hydrogen atom from the drugs thereby promoting a process of radical coupling. This results in a reduction of the violet color of DPPH with the formation of the yellow colored 2,2-diphenyl-1-picrylhydrazine (DPPH2). The decrease in the intensity of the violet color is used to measure the concentration of the drugs. All measurements are made at λ = 520 nm on methanolic solutions of the reagent and drugs. Beer's law is obeyed for the studied drugs in the range 2-36 µg ml−1 with correlation coefficients not less than 0.9992. All procedures hold well accuracy and precision when applied to the analysis of the cited fluoroquinolones in different dosage forms with good recovery percent ranged from 98.88±0.40 to 100.99±0.44 without interference from additives. Full article
1719 KiB  
Article
Influence of Lipophilicity on the Antimycobacterial Activity of the Hydrochlorides of Piperidinylethyl Esters of Ortho-Substituted Phenylcarbamic Acids
by K. Waisser, K. Dražková, J. Čižmárik and J. Kaustová
Sci. Pharm. 2004, 72(1), 43-49; https://doi.org/10.3797/scipharm.aut-04-05 - 11 Mar 2004
Cited by 13 | Viewed by 1060
Abstract
A series of 14 hydrochlorides of piperidinylethyl esters of orthosubstituted phenylcarbamic acids were evaluated for in vitro antimycobacterial activity against the strains of Mycobacterium tuberculosis, Mycobactenum kansasii and Mycobactenum avium. In vitro antimycobacterial activrty becomes higher with increasing hydrophobicity of the [...] Read more.
A series of 14 hydrochlorides of piperidinylethyl esters of orthosubstituted phenylcarbamic acids were evaluated for in vitro antimycobacterial activity against the strains of Mycobacterium tuberculosis, Mycobactenum kansasii and Mycobactenum avium. In vitro antimycobacterial activrty becomes higher with increasing hydrophobicity of the substituents. The alkoxy group is not necessary in order for the basic ethyl esters of phenylcarbamic acids to display antimycobacterial activity. Full article
2180 KiB  
Article
Synthesis of Tetrahydro-2H-[1,3,5]thiadiazine-5-(4-pyridylcarboxamido)-2-thione with antitubercular activity
by D. Sriram, K. Jyothi Mallika and P. Yogeeswari
Sci. Pharm. 2004, 72(1), 35-41; https://doi.org/10.3797/scipharm.aut-04-04 - 9 Mar 2004
Cited by 11 | Viewed by 1107
Abstract
3-Substituted-5-(4-pyridylcarboxamide)tetrahydro-2H-[1,3,5]thiadizine-2-thione derivatives (1-9) were synthesized as derivatives of isoniazid (INH) to overcome the resistance developed with its therapeutic use. The structures were confirmed by their spectral and elemental analyses data. These derivatives revealed higher lipophilicity compared with INH. The [...] Read more.
3-Substituted-5-(4-pyridylcarboxamide)tetrahydro-2H-[1,3,5]thiadizine-2-thione derivatives (1-9) were synthesized as derivatives of isoniazid (INH) to overcome the resistance developed with its therapeutic use. The structures were confirmed by their spectral and elemental analyses data. These derivatives revealed higher lipophilicity compared with INH. The antimycobacterial activity of the synthesized compounds and INH was evaluated in vitro against Mycobacterium tuberculosis H37Rv at 6.25 µg/ml in BACTEC 12B medium using the BACTEC 460 radiometric system. The derivatives exhibited antitubercular activity. Full article
2950 KiB  
Article
Alpha amylase inhibitory activitv of some plant extracts with hyporrlycemic activity
by Rawand S. Abu Soud, Lmad I. Hamdan and Fatma U. Afifi
Sci. Pharm. 2004, 72(1), 25-33; https://doi.org/10.3797/scipharm.aut-04-03 - 6 Mar 2004
Cited by 22 | Viewed by 2067
Abstract
Thirteen plant species which are claimed to have anti-diabetic activity (based on folk medicine and/or scientific reports) were tested for alpha amylase inhibitory activity. Two of the screened plants exhibited significant (more than 80%) alpha amylase inhibitory activity. lC50 of these plants [...] Read more.
Thirteen plant species which are claimed to have anti-diabetic activity (based on folk medicine and/or scientific reports) were tested for alpha amylase inhibitory activity. Two of the screened plants exhibited significant (more than 80%) alpha amylase inhibitory activity. lC50 of these plants was estimated based on the dried crude extract and found to be 0.08, and 0.2 mg/ml for Aloe vera and Paronychia argentea respectively. In A. vera the activity was most likely due to cinnamic acid derivatives. In P. argentea the activity was attributed to flavonoid components. These findings support the hypoglycemic activity of these species and give insight about the potential mechanism of their hypoglycemic activity. Full article
2925 KiB  
Article
Synthese von thienoanalogen Zimtsäurederivaten mit Hilfe der Heck Reaktion [1]
by Thomas Erker and Norbert Handler
Sci. Pharm. 2004, 72(1), 15-23; https://doi.org/10.3797/scipharm.aut-04-02 - 3 Mar 2004
Cited by 4 | Viewed by 1125
Abstract
Ausgehend vom entsprechenden Bromthiophenderivat und Acrylsäurederivat wurden die optimalen Bedingungen für eine Heck-Reaktion erarbeitet. Dabei wurde der Einfluss der Mengenverhältnisse der Reaktanden bzw. des Katalysators und Co-Katalysators sowie des Lösungsmittels und der Temperatur auf die Umsetzung untersucht. Full article
3844 KiB  
Article
Die Emerson-Reaktion des Salbutamols
by H.-J. Kallmayer and H.-J. Engels
Sci. Pharm. 2004, 72(1), 1-13; https://doi.org/10.3797/scipharm.aut-04-01 - 1 Mar 2004
Viewed by 1369
Abstract
Kaliumhexacyanoferrat(lll) kuppelt 4-Aminoantipyrin (1) mit Salbutamol (2) oxidativ nach Emerson zu den roten E-/Z-isomeren 1,4-Benzochinon-4-iminen 7a und b. Die Desalkylierung des Salbutamols wird als Grob'sche Fragmentierung interpretiert. Full article
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