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Volume 72
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10.3797/scipharm.aut-04-05
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Article

Influence of Lipophilicity on the Antimycobacterial Activity of the Hydrochlorides of Piperidinylethyl Esters of Ortho-Substituted Phenylcarbamic Acids

by
K. Waisser
1,*,
K. Dražková
1,
J. Čižmárik
2 and
J. Kaustová
3
1
Department of Inorganic and Organic Chemistry, Charles Universtty, Faculty of Pharmacy, Heyrovského 1203, CZ-500 05 Hradec Králové, Czech Republic
2
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Commenius Universtty, SK-832 32 Bratislava, Slovakia
3
Department for the Diagnostics of Mycobacteria, Regional Institute of PuMic Health, Ostrava, Partyzánské nám. 7, CZ-728 892 Ostrava, Czech Republic
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2004, 72(1), 43-49; https://doi.org/10.3797/scipharm.aut-04-05
Submission received: 12 September 2003 / Revised: 13 October 2003 / Accepted: 13 October 2003 / Published: 11 March 2004
Versions Notes

Abstract

A series of 14 hydrochlorides of piperidinylethyl esters of orthosubstituted phenylcarbamic acids were evaluated for in vitro antimycobacterial activity against the strains of Mycobacterium tuberculosis, Mycobactenum kansasii and Mycobactenum avium. In vitro antimycobacterial activrty becomes higher with increasing hydrophobicity of the substituents. The alkoxy group is not necessary in order for the basic ethyl esters of phenylcarbamic acids to display antimycobacterial activity.
Keywords: phen ylcarbamic acids; tuberculostatics; mycobacterium; M. tuberculosis phen ylcarbamic acids; tuberculostatics; mycobacterium; M. tuberculosis

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MDPI and ACS Style

Waisser, K.; Dražková, K.; Čižmárik, J.; Kaustová, J. Influence of Lipophilicity on the Antimycobacterial Activity of the Hydrochlorides of Piperidinylethyl Esters of Ortho-Substituted Phenylcarbamic Acids. Sci. Pharm. 2004, 72, 43-49. https://doi.org/10.3797/scipharm.aut-04-05

AMA Style

Waisser K, Dražková K, Čižmárik J, Kaustová J. Influence of Lipophilicity on the Antimycobacterial Activity of the Hydrochlorides of Piperidinylethyl Esters of Ortho-Substituted Phenylcarbamic Acids. Scientia Pharmaceutica. 2004; 72(1):43-49. https://doi.org/10.3797/scipharm.aut-04-05

Chicago/Turabian Style

Waisser, K., K. Dražková, J. Čižmárik, and J. Kaustová. 2004. "Influence of Lipophilicity on the Antimycobacterial Activity of the Hydrochlorides of Piperidinylethyl Esters of Ortho-Substituted Phenylcarbamic Acids" Scientia Pharmaceutica 72, no. 1: 43-49. https://doi.org/10.3797/scipharm.aut-04-05

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