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11 March 2004

Influence of Lipophilicity on the Antimycobacterial Activity of the Hydrochlorides of Piperidinylethyl Esters of Ortho-Substituted Phenylcarbamic Acids

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and
1
Department of Inorganic and Organic Chemistry, Charles Universtty, Faculty of Pharmacy, Heyrovského 1203, CZ-500 05 Hradec Králové, Czech Republic
2
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Commenius Universtty, SK-832 32 Bratislava, Slovakia
3
Department for the Diagnostics of Mycobacteria, Regional Institute of PuMic Health, Ostrava, Partyzánské nám. 7, CZ-728 892 Ostrava, Czech Republic
*
Author to whom correspondence should be addressed.
Sci. Pharm.2004, 72(1), 43-49;https://doi.org/10.3797/scipharm.aut-04-05
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Abstract

A series of 14 hydrochlorides of piperidinylethyl esters of orthosubstituted phenylcarbamic acids were evaluated for in vitro antimycobacterial activity against the strains of Mycobacterium tuberculosis, Mycobactenum kansasii and Mycobactenum avium. In vitro antimycobacterial activrty becomes higher with increasing hydrophobicity of the substituents. The alkoxy group is not necessary in order for the basic ethyl esters of phenylcarbamic acids to display antimycobacterial activity.

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