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Volume 72
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10.3797/scipharm.aut-04-07
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Article

Spectrophotometric Determination of Aciclovir, Cefepirne Hydrochloride, Etamsylate and Metoclopramide Hydrochloride Usina 1,10 Phenanttrroline—Fe(lll) Reaqent

by
Marwa S. Elazazy
*,
Abdalla Shalaby
,
M. N. Elbolkiny
and
Hawa M. Khalil
Analytical Chemistry Department, Faculty of Pharmacy- Zagazig University, Zagazig, Eygpt
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2004, 72(1), 73-86; https://doi.org/10.3797/scipharm.aut-04-07
Submission received: 10 June 2002 / Revised: 13 October 2003 / Accepted: 13 October 2003 / Published: 15 March 2004
Versions Notes

Abstract

A simple, rapid, sensitive and accurate method for the determination of aciclovir, cefepime HCI, etamsylate and metoclopramide HCI in pure form and in pharmaceutical formulations is developed.The method is based on the fomabon of tris(o-phenanthroline) iron(ll) complex (Ferroin) upon the reaction of the ated drugs wrth iron(lll )-o- phenanthroline mixture. The ferroin complex is colorimetncally measured at λmax 510 nm against a reagent blank. 0ptimization of the experimental conditions is described. Beer's law is obeyed in the concentration range from 0.25–30 µg ml−1 with molar absorpitivities (ε) ranging from 4.796 x 103–9.51 2 x 104 L.mol−1.cm−1 and Sandell sensitivities (S) of 2.129 x 10−3–34.5 x 10−3 µg cm−2. The developed method is applied successfully for the determination of the cited drugs in pure forms and in the corresponding pharmaceutical formulations without any interferences from common excipients.
Keywords: Spectrophotometry; 1,10-Phenanthroline—Fe(lll) reagent; Pure forms; Pharmaceutical formulations Spectrophotometry; 1,10-Phenanthroline—Fe(lll) reagent; Pure forms; Pharmaceutical formulations

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MDPI and ACS Style

Elazazy, M.S.; Shalaby, A.; Elbolkiny, M.N.; Khalil, H.M. Spectrophotometric Determination of Aciclovir, Cefepirne Hydrochloride, Etamsylate and Metoclopramide Hydrochloride Usina 1,10 Phenanttrroline—Fe(lll) Reaqent. Sci. Pharm. 2004, 72, 73-86. https://doi.org/10.3797/scipharm.aut-04-07

AMA Style

Elazazy MS, Shalaby A, Elbolkiny MN, Khalil HM. Spectrophotometric Determination of Aciclovir, Cefepirne Hydrochloride, Etamsylate and Metoclopramide Hydrochloride Usina 1,10 Phenanttrroline—Fe(lll) Reaqent. Scientia Pharmaceutica. 2004; 72(1):73-86. https://doi.org/10.3797/scipharm.aut-04-07

Chicago/Turabian Style

Elazazy, Marwa S., Abdalla Shalaby, M. N. Elbolkiny, and Hawa M. Khalil. 2004. "Spectrophotometric Determination of Aciclovir, Cefepirne Hydrochloride, Etamsylate and Metoclopramide Hydrochloride Usina 1,10 Phenanttrroline—Fe(lll) Reaqent" Scientia Pharmaceutica 72, no. 1: 73-86. https://doi.org/10.3797/scipharm.aut-04-07

APA Style

Elazazy, M. S., Shalaby, A., Elbolkiny, M. N., & Khalil, H. M. (2004). Spectrophotometric Determination of Aciclovir, Cefepirne Hydrochloride, Etamsylate and Metoclopramide Hydrochloride Usina 1,10 Phenanttrroline—Fe(lll) Reaqent. Scientia Pharmaceutica, 72(1), 73-86. https://doi.org/10.3797/scipharm.aut-04-07

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