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Volume 68
Issue 3
10.3797/scipharm.aut-00-26
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Article

Kinetic Method for the Determination of Cisapride in Pharmaceutical Preparations

by
Ekram M. Hassan
1,*,
Mohammed E.M. Hagga
2 and
Haya I. Al Johar
2
1
Department of Analytical Chemistry, College of Pharmacy, Alexandria University, Egypt
2
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2000, 68(3), 281-296; https://doi.org/10.3797/scipharm.aut-00-26
Submission received: 9 May 2000 / Revised: 21 July 2000 / Accepted: 21 July 2000 / Published: 4 August 2000
Versions Notes

Abstract

An accurate kinetic method for the determination of cisapride is described. The method is based on the reaction of cisapride with potassium dichromate in 2.5 M sulphuric acid at room temperature for a fixed-time of 10 min, afterwards the absorbance of the reaction product is measured at 527 nm. The concentration of cisapride is computed using the corresponding calibration equation for the fixed-time method. The method is applied successfully to commercial tablets and oral suspension dosage forms. The results obtained are compared statistically with the British Pharmacopoeia method. The determination of cisapride by other kinetic methods is feasible with calibration equation obtained but the fixed-time method proves to be more applicable.
Keywords: Kinetic method; cisapride; pharmaceutical preparations Kinetic method; cisapride; pharmaceutical preparations

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MDPI and ACS Style

Hassan, E.M.; Hagga, M.E.M.; Al Johar, H.I. Kinetic Method for the Determination of Cisapride in Pharmaceutical Preparations. Sci. Pharm. 2000, 68, 281-296. https://doi.org/10.3797/scipharm.aut-00-26

AMA Style

Hassan EM, Hagga MEM, Al Johar HI. Kinetic Method for the Determination of Cisapride in Pharmaceutical Preparations. Scientia Pharmaceutica. 2000; 68(3):281-296. https://doi.org/10.3797/scipharm.aut-00-26

Chicago/Turabian Style

Hassan, Ekram M., Mohammed E.M. Hagga, and Haya I. Al Johar. 2000. "Kinetic Method for the Determination of Cisapride in Pharmaceutical Preparations" Scientia Pharmaceutica 68, no. 3: 281-296. https://doi.org/10.3797/scipharm.aut-00-26

APA Style

Hassan, E. M., Hagga, M. E. M., & Al Johar, H. I. (2000). Kinetic Method for the Determination of Cisapride in Pharmaceutical Preparations. Scientia Pharmaceutica, 68(3), 281-296. https://doi.org/10.3797/scipharm.aut-00-26

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