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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
Open AccessArticle

Kinetic Method for the Determination of Cisapride in Pharmaceutical Preparations

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Department of Analytical Chemistry, College of Pharmacy, Alexandria University, Egypt
2
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
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Author to whom correspondence should be addressed.
Sci. Pharm. 2000, 68(3), 281-296; https://doi.org/10.3797/scipharm.aut-00-26
Received: 9 May 2000 / Revised: 21 July 2000 / Accepted: 21 July 2000 / Published: 4 August 2000
An accurate kinetic method for the determination of cisapride is described. The method is based on the reaction of cisapride with potassium dichromate in 2.5 M sulphuric acid at room temperature for a fixed-time of 10 min, afterwards the absorbance of the reaction product is measured at 527 nm. The concentration of cisapride is computed using the corresponding calibration equation for the fixed-time method. The method is applied successfully to commercial tablets and oral suspension dosage forms. The results obtained are compared statistically with the British Pharmacopoeia method. The determination of cisapride by other kinetic methods is feasible with calibration equation obtained but the fixed-time method proves to be more applicable.
Keywords: Kinetic method; cisapride; pharmaceutical preparations Kinetic method; cisapride; pharmaceutical preparations
MDPI and ACS Style

Hassan, E.M.; Hagga, M.E.; Al Johar, H.I. Kinetic Method for the Determination of Cisapride in Pharmaceutical Preparations. Sci. Pharm. 2000, 68, 281-296.

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