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3-Propynyl-2-substituted Carboxylic Acid Derivatives of Quinazolinone

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Sci. Pharm. 2000, 68(3), 275-279;
Submission received: 31 January 2000 / Revised: 11 July 2000 / Accepted: 11 July 2000 / Published: 1 August 2000


Alkylation of quinazolinone-2-carboxylic acids with propargyl bromide in dimethylformamide in the presence of potassium carbonate afforded 3-prop-2-ynyl quinazolinone-2-substituted carboxylic acid derivatives. Further reaction of 4b-c produced 5b-c, which indicates that N-alkylation occurs before esterification with a propynyl moiety.
Keywords: Quinazolinone; Carboxylic acid; Prop-2-ynylester Quinazolinone; Carboxylic acid; Prop-2-ynylester

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MDPI and ACS Style

USIFOH, C.O. 3-Propynyl-2-substituted Carboxylic Acid Derivatives of Quinazolinone. Sci. Pharm. 2000, 68, 275-279.

AMA Style

USIFOH CO. 3-Propynyl-2-substituted Carboxylic Acid Derivatives of Quinazolinone. Scientia Pharmaceutica. 2000; 68(3):275-279.

Chicago/Turabian Style

USIFOH, C. O. 2000. "3-Propynyl-2-substituted Carboxylic Acid Derivatives of Quinazolinone" Scientia Pharmaceutica 68, no. 3: 275-279.

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