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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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3-Propynyl-2-substituted Carboxylic Acid Derivatives of Quinazolinone

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Sci. Pharm. 2000, 68(3), 275-279; https://doi.org/10.3797/scipharm.aut-00-25
Received: 31 January 2000 / Revised: 11 July 2000 / Accepted: 11 July 2000 / Published: 1 August 2000
Alkylation of quinazolinone-2-carboxylic acids with propargyl bromide in dimethylformamide in the presence of potassium carbonate afforded 3-prop-2-ynyl quinazolinone-2-substituted carboxylic acid derivatives. Further reaction of 4b-c produced 5b-c, which indicates that N-alkylation occurs before esterification with a propynyl moiety.
Keywords: Quinazolinone; Carboxylic acid; Prop-2-ynylester Quinazolinone; Carboxylic acid; Prop-2-ynylester
MDPI and ACS Style

USIFOH, C.O. 3-Propynyl-2-substituted Carboxylic Acid Derivatives of Quinazolinone. Sci. Pharm. 2000, 68, 275-279.

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