Synthesis and Anticalcium Activity of New Compounds Containing the 2,3-Dihydro-1,4-dioxino[2,3-b]pyridine System

Sánchez, I.; Pujol, MD.; Guillaumet, G.; Massingham, R.; Monteil, A.; Dureng, G.; Winslow, E.

doi:10.3797/scipharm.aut-00-14

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Article

5 April 2000

6 Pages

Synthesis and Anticalcium Activity of New Compounds Containing the 2,3-Dihydro-1,4-dioxino[2,3-b]pyridine System

and

Laboratori de Química Farmacèutica, Fac. Farmàcia, Universitat de Barcelona, Avda. Diagonal 643, 08028 Barcelona (Spain

Institut de Chimie Organique et Analytique associé au CNRS, Université d'Orléans, BP-6957, 45067 Orléans, Cedex 2 (France)

UCB Pharma, Pharmaceutical Sector, Chemin du Foriest, B-1420 Braine-L'Alleud (Belgique)

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Laboratoire RL-CERM, ZI La Varenne, rue H. Goudier, 63203 Riom, Cedex (France)

Sci. Pharm.2000, 68(2), 159-164;https://doi.org/10.3797/scipharm.aut-00-14

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Abstract

Summary: New compounds (3 and 4) possesing the 2,3-dihydro-1,4-dioxino[2,3-b]pyridine group were synthesized and tested as calcium antagonist agents. Both of them showed moderate anticalcium activity.

Keywords:

1,4-dioxino[2,3-b]pyridine; 1,4-benzodioxin; anticalcium activity

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