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Androgenic and Anabolic Activities of Some Newly Synthesized Epiandrosterone and Progesterone Derivatives.

1
Department of Pharmaceutical Scieiices (Pharmacology group) National Research Center, Dokki, Cairo, Egypt
2
Department of Pathology, Theodore Bilharz Research Institute, Imbaba, Giza, Egypt
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Author to whom correspondence should be addressed.
Sci. Pharm. 2000, 68(2), 141-157; https://doi.org/10.3797/scipharm.aut-00-13
Received: 29 February 2000 / Revised: 4 May 2000 / Accepted: 4 May 2000 / Published: 5 May 2000
Derivatives of eplandrosterone and progesterone were synthesized. The androgenic and the anabolic activities of some of tlieln were investigated on prepubertal male albino rats of 21 days old by:-i determining tlie weight gain of the body, levator ani muscle, ventral prostate gland, testis, selniilal vesicles, vas deferens and epididymis, ii- estimation of serum luteinizing (LH) hormone, iii- histopatliological examination of the testis and ventral prostate glands. The results from this study showed that the presence of an appended substituted 2- aminopyridine ring at the C- 17 of testosterone gave the maximum androgenic activity, whereas the presence of a substituted piperidine ring fused to ring D of 5 α- androstane exhibited tlie maximum anabolic activity. However, fusion of a pyrazoline moiety with the ring D of 5 α- androstane led to a compound with considerable androgenic and anabolic activity.
Keywords: epiandrosterone; progesterone; androgenic activity; anabolic activity; prepubertal rat; male sex accessory glands; luteinizing hormone; histopathology epiandrosterone; progesterone; androgenic activity; anabolic activity; prepubertal rat; male sex accessory glands; luteinizing hormone; histopathology
MDPI and ACS Style

Maklad, Y.A.; Nosseir, M.M. Androgenic and Anabolic Activities of Some Newly Synthesized Epiandrosterone and Progesterone Derivatives.. Sci. Pharm. 2000, 68, 141-157.

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