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Diseases, Volume 9, Issue 4

December 2021 - 29 articles

Cover Story:

In about 25% of patients with spontaneous subarachnoid hemorrhage, a bleeding source cannot be identified. A modified Rankin scale (mRs) was used to measure the influence on quality of life. An SF-36 questionnaire was used for long-term follow-up.
In short-term outcome, a significant improvement from discharge until follow-up was identified with subsequent rehabilitation, but not in the group without rehabilitation. If PM-SAH is compared to a standard population, a reduction in quality of life was identified by the SF-36 questionnaire. Even though there were better mRs at discharge for patients without subsequent rehabilitation, mRs of rehabilitants became nearly even. Patients with good mRs also reach a high HRQoL without rehabilitation. Therefore, subsequent rehabilitation should be recommended on an individual basis.

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Articles (29)

  • Article
  • Open Access
4 Citations
6,330 Views
10 Pages

13 November 2021

Background: Foodborne diseases are a major source of concern in USA. These diseases are a burden on public health and significantly contribute to the cost of health care. There is an urgent need to understand the contributing factors for such outbrea...

  • Article
  • Open Access
1 Citations
2,895 Views
16 Pages

Anticancer Impact of Nitric Oxide (NO) and NO Combination with SMYD-3 Inhibitor on Breast Carcinomas

  • Jenna L. Gordon,
  • Kristin J. Hinsen,
  • Melissa M. Reynolds and
  • Mark A. Brown

12 November 2021

Despite enormous advances in the detection and treatment of breast cancer, it still remains the leading cancer diagnosis and has the second highest mortality rate. Thus, breast cancer research is a high priority for academics and clinicians alike. Ba...

  • Article
  • Open Access
9 Citations
3,849 Views
14 Pages

Modulated Electro-Hyperthermic (mEHT) Treatment in the Therapy of Inoperable Pancreatic Cancer Patients—A Single-Center Case-Control Study

  • Flora Greta Petenyi,
  • Tamas Garay,
  • Dorottya Muhl,
  • Blanka Izso,
  • Adam Karaszi,
  • Erika Borbenyi,
  • Magdolna Herold,
  • Zoltan Herold,
  • Attila Marcell Szasz and
  • Magdolna Dank

3 November 2021

Our present oncological treatment arsenal has limited treatment options for pancreatic ductal adenocarcinoma (PDAC). Extended reviews have shown the benefits of hyperthermia for PDAC, supporting the perspectives with the improvements of the treatment...

  • Article
  • Open Access
22 Citations
5,266 Views
11 Pages

Antibiotic Susceptibility, Biofilm Production, and Detection of mecA Gene among Staphylococcus aureus Isolates from Different Clinical Specimens

  • Upama Gaire,
  • Upendra Thapa Shrestha,
  • Sanjib Adhikari,
  • Nabaraj Adhikari,
  • Anup Bastola,
  • Komal Raj Rijal,
  • Prakash Ghimire and
  • Megha Raj Banjara

1 November 2021

The increasing incidence of methicillin-resistant and biofilm-forming S. aureus isolates in hospital settings is a gruesome concern today. The main objectives of this study were to determine the burden of S. aureus in clinical samples, assess their a...

  • Review
  • Open Access
27 Citations
6,506 Views
25 Pages

Exploring the Inflammatory Pathogenesis of Colorectal Cancer

  • Ahamed A Khalyfa,
  • Shil Punatar,
  • Rida Aslam and
  • Alex Yarbrough

30 October 2021

Colorectal cancer is one of the most commonly diagnosed cancers worldwide. Traditionally, mechanisms of colorectal cancer formation have focused on genetic alterations including chromosomal damage and microsatellite instability. In recent years, ther...

  • Review
  • Open Access
15 Citations
8,239 Views
10 Pages

29 October 2021

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), otherwise known as COVID-19, has challenged healthcare systems at an international level. COVID-19 suppresses the immune system by causing a systemic inflammatory response, also known as c...

  • Review
  • Open Access
18 Citations
6,505 Views
39 Pages

MYCN in Neuroblastoma: “Old Wine into New Wineskins”

  • Maria Braoudaki,
  • Kyriaki Hatziagapiou,
  • Apostolos Zaravinos and
  • George I. Lambrou

29 October 2021

MYCN Proto-Oncogene, BHLH Transcription Factor (MYCN) has been one of the most studied genes in neuroblastoma. It is known for its oncogenetic mechanisms, as well as its role in the prognosis of the disease and it is considered one of the prominent t...

  • Review
  • Open Access
3 Citations
5,647 Views
15 Pages

Stem Cell Therapy for Post-Traumatic Stress Disorder: A Novel Therapeutic Approach

  • Dhir Gala,
  • Vikram Gurusamy,
  • Krishna Patel,
  • Sreedevi Damodar,
  • Girish Swaminath and
  • Gautam Ullal

29 October 2021

Stem cell therapy is a rapidly evolving field of regenerative medicine being employed for the management of various central nervous system disorders. The ability to self-renew, differentiate into specialized cells, and integrate into neuronal network...

  • Article
  • Open Access
7 Citations
5,849 Views
20 Pages

Patient Heterogeneity in Acute Myeloid Leukemia: Leukemic Cell Communication by Release of Soluble Mediators and Its Effects on Mesenchymal Stem Cells

  • Elise Aasebø,
  • Annette K. Brenner,
  • Maria Hernandez-Valladares,
  • Even Birkeland,
  • Olav Mjaavatten,
  • Håkon Reikvam,
  • Frode Selheim,
  • Frode S. Berven and
  • Øystein Bruserud

16 October 2021

Acute myeloid leukemia (AML) is an aggressive bone marrow malignancy, and non-leukemic stromal cells (including mesenchymal stem cells, MSCs) are involved in leukemogenesis and show AML-supporting effects. We investigated how constitutive extracellul...

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Diseases - ISSN 2079-9721Creative Common CC BY license