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Diseases, Volume 7, Issue 1

2019 March - 32 articles

Cover Story: Myogenin–Cre-mediated deletion of the SET and MYND Domain 1 (SMYD1) lysine methyl transferase in skeletal muscle results in perinatal death in mice. Severe defects in pectoral (white arrows) and sternohyoid (yellow arrows) muscles, as well as accumulation of excessive brown adipose tissue (pink), were observed in the conditional knockout (CKO, right) relative to wild-type (WT, left). Dorsal muscles (blue arrows) were also significantly diminished, whereas other skeletal muscles were left unscathed. Shown are the in situ Myogenin hybridization sections at embryonic (E) stage (15.5 days). View this paper.
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Articles (32)

  • Article
  • Open Access
5 Citations
4,599 Views
8 Pages

Handgrip strength (HS) and knee extensor muscle strength (KEMS) showed a negative correlation with the Disabilities of the Arm, Shoulder, and Hand (DASH) score at one month following cardiac surgery. We performed a longitudinal study to examine chang...

  • Communication
  • Open Access
4,679 Views
4 Pages

Ancient Egyptians smeared a mixture of dark soil on their eyelids and believed it protected eyes from unknown forces (illness). Recent studies have proven that the dark soil across the Nile River is rich in natural compounds including lead sulfide, w...

  • Article
  • Open Access
18 Citations
7,969 Views
7 Pages

Keeping an Eye on Perimenopausal and Postmenopausal Endometriosis

  • Michail Matalliotakis,
  • Charoula Matalliotaki,
  • Alexandra Trivli,
  • Maria I. Zervou,
  • Ioannis Kalogiannidis,
  • Maria Tzardi,
  • Ioannis Matalliotakis,
  • Aydin Arici and
  • George N. Goulielmos

Introduction: We aimed to describe and review the epidemiological aspect of the disease pattern of a series of perimenopausal and postmenopausal women with a histology confirmation of endometriosis. Material and Methods: We retrospectively examined t...

  • Review
  • Open Access
82 Citations
19,564 Views
14 Pages

Salmonella not only causes acute infections, but can also cause patients to become chronic “asymptomatic” carriers. Salmonella has been verified as a pathogenic factor that contributes to chronic inflammation and carcinogenesis. This revi...

  • Review
  • Open Access
44 Citations
9,860 Views
12 Pages

The Therapeutic Implications of the Gut Microbiome and Probiotics in Patients with NAFLD

  • Brandon J. Perumpail,
  • Andrew A. Li,
  • Nimy John,
  • Sandy Sallam,
  • Neha D. Shah,
  • Waiyee Kwong,
  • George Cholankeril,
  • Donghee Kim and
  • Aijaz Ahmed

25 February 2019

Recent breakthrough in our understanding pertaining to the pathogenesis of nonalcoholic fatty liver disease (NAFLD) has pointed to dysregulation or derangement of the gut microbiome, also known as dysbiosis. This has led to growing interest in probio...

  • Article
  • Open Access
8 Citations
4,298 Views
9 Pages

24 February 2019

The relationship between hepatitis C virus (HCV) infection and C-reactive protein (CRP), which is an inflammatory biomarker, is limited in studies with the general population. It was hypothesized that changes in CRP levels are genotype-dependent in t...

  • Feature Paper
  • Article
  • Open Access
21 Citations
6,324 Views
16 Pages

Factors Influencing Quality of Life in Breast Cancer Patients Six Months after the Completion of Chemotherapy

  • Maria Lavdaniti,
  • Dimitra Anna Owens,
  • Polixeni Liamopoulou,
  • Kalliopi Marmara,
  • Efrosini Zioga,
  • Michael S. Mantzanas,
  • Eftychia Evangelidou and
  • Eugenia Vlachou

24 February 2019

Purpose: To assess breast cancer patients’ quality of life six months after the completion of adjuvant chemotherapy, and to investigate factors affecting this. Methods: The study was conducted in one large hospital located in a major Greek city...

  • Feature Paper
  • Review
  • Open Access
24 Citations
6,634 Views
12 Pages

Social Interaction Improved by Oxytocin in the Subclass of Autism with Comorbid Intellectual Disabilities

  • Haruhiro Higashida,
  • Toshio Munesue,
  • Hirotaka Kosaka,
  • Hidenori Yamasue,
  • Shigeru Yokoyama and
  • Mitsuru Kikuchi

22 February 2019

Approximately half of all autism spectrum disorder (ASD) individuals suffer from comorbid intellectual disabilities. Furthermore, the prevalence of epilepsy has been estimated to be 46% of patients with low intelligence quotient. It is important to i...

  • Feature Paper
  • Article
  • Open Access
4 Citations
4,908 Views
10 Pages

Inhibitory Effect of Ionizing Radiation on Echinococcus granulosus Hydatid Cyst

  • Yumin Zhao,
  • Weifeng Gui,
  • Yishu Zhang,
  • Gang Mo,
  • Dayu Li and
  • Shigui Chong

18 February 2019

Background: Heavy ion radiation has more advantages than traditional radiation therapy in the treatment of cancer, mainly because of its superior biological effects. However, there is currently no reliable evidence that heavy ion radiation can induce...

  • Review
  • Open Access
63 Citations
11,233 Views
22 Pages

Impact of Gut Dysbiosis on Neurohormonal Pathways in Chronic Kidney Disease

  • Nima H. Jazani,
  • Javad Savoj,
  • Michael Lustgarten,
  • Wei Ling Lau and
  • Nosratola D. Vaziri

13 February 2019

Chronic kidney disease (CKD) is a worldwide major health problem. Traditional risk factors for CKD are hypertension, obesity, and diabetes mellitus. Recent studies have identified gut dysbiosis as a novel risk factor for the progression CKD and its c...

  • Review
  • Open Access
155 Citations
14,636 Views
11 Pages

Roles of PI3K/AKT/GSK3 Pathway Involved in Psychiatric Illnesses

  • Satoru Matsuda,
  • Yuka Ikeda,
  • Mutsumi Murakami,
  • Yukie Nakagawa,
  • Ai Tsuji and
  • Yasuko Kitagishi

13 February 2019

Psychiatric illnesses may be qualified to the cellular impairments of the function for survival or death in neurons, which may consequently appear as abnormalities in the neuroplasticity. The molecular mechanism has not been well understood, however,...

  • Article
  • Open Access
46 Citations
10,778 Views
11 Pages

7 February 2019

(1) Background: Salmonella infections are a major cause of illnesses in the United States. Each year around 450 people die from the disease and more than 23,000 people are hospitalized. Salmonella outbreaks are commonly associated with eggs, meat and...

  • Feature Paper
  • Article
  • Open Access
7 Citations
6,415 Views
12 Pages

Timely Interventions for Children with ADHD through Web-Based Monitoring Algorithms

  • Julia Oppenheimer,
  • Oluwafemi Ojo,
  • Annalee Antonetty,
  • Madeline Chiujdea,
  • Stephanie Garcia,
  • Sarah Weas,
  • Tobias Loddenkemper,
  • Eric Fleegler and
  • Eugenia Chan

7 February 2019

The aim of this study was to evaluate an automated trigger algorithm designed to detect potentially adverse events in children with Attention-Deficit/Hyperactivity Disorder (ADHD), who were monitored remotely between visits. We embedded a trigger alg...

  • Review
  • Open Access
133 Citations
11,385 Views
14 Pages

Assessing Gait in Parkinson’s Disease Using Wearable Motion Sensors: A Systematic Review

  • Lorenzo Brognara,
  • Pierpaolo Palumbo,
  • Bernd Grimm and
  • Luca Palmerini

5 February 2019

Abstract: Parkinson’s disease (PD) is a progressive neurodegenerative disorder. Gait impairments are common among people with PD. Wearable sensor systems can be used for gait analysis by providing spatio-temporal parameters useful to investigat...

  • Article
  • Open Access
34 Citations
7,719 Views
8 Pages

The Relationship between Walking Speed and Step Length in Older Aged Patients

  • Yuji Morio,
  • Kazuhiro P. Izawa,
  • Yoshitsugu Omori,
  • Hironobu Katata,
  • Daisuke Ishiyama,
  • Shingo Koyama and
  • Yoshihisa Yamano

2 February 2019

Compared with elderly people who have not experienced falls, those who have were reported to have a shortened step length, large fluctuations in their pace, and a slow walking speed. The purpose of this study was to elucidate the step length required...

  • Review
  • Open Access
20 Citations
7,480 Views
30 Pages

Autophagy Intertwines with Different Diseases—Recent Strategies for Therapeutic Approaches

  • Janani Ramesh,
  • Larance Ronsard,
  • Anthony Gao and
  • Bhuvarahamurthy Venugopal

1 February 2019

Autophagy is a regular and substantial “clear-out process” that occurs within the cell and that gets rid of debris that accumulates in membrane-enclosed vacuoles by using enzyme-rich lysosomes, which are filled with acids that degrade the...

  • Article
  • Open Access
4 Citations
3,730 Views
12 Pages

The Presence of Gut Microbial Genes Encoding Bacterial Genotoxins or Pro-Inflammatory Factors in Stool Samples from Individuals with Colorectal Neoplasia

  • Ramón Gómez-Moreno,
  • María González-Pons,
  • Marievelisse Soto-Salgado,
  • Marcia Cruz-Correa and
  • Abel Baerga-Ortiz

1 February 2019

Gut bacterial toxins are thought to contribute to the development of colorectal cancer (CRC). This study examines the presence of specific gut bacterial toxin genes in stool samples from individuals with colorectal neoplasia (adenomas and/or CRC). Th...

  • Review
  • Open Access
22 Citations
10,267 Views
12 Pages

30 January 2019

Delirium is a neuropsychiatric syndrome often manifesting in acute disease conditions, and with a greater prevalence in the older generation. Delirium in the Emergency Department (ED) is a highly prevalent problem that typically goes unnoticed by hea...

  • Article
  • Open Access
32 Citations
7,898 Views
10 Pages

Prevalence of Tinea Capitis among Children in Osogbo, Nigeria, and the Associated Risk Factors

  • Yemisi O. Adesiji,
  • Busayo F. Omolade,
  • Isaac A. Aderibigbe,
  • Oluwabunmi V. Ogungbe,
  • Olusegun A. Adefioye,
  • Samuel A. Adedokun,
  • Margaret A. Adekanle and
  • Richard O. Ojedele

27 January 2019

Tinea capitis is a fungi infection of the scalp that disproportionately affects children in rural and underserved communities in Nigeria. A case-control study was conducted to identify the causative agents and factors that predispose school pupils to...

  • Review
  • Open Access
32 Citations
14,337 Views
32 Pages

Modulating Effect of Diet on Alzheimer’s Disease

  • Paloma Fernández-Sanz,
  • Daniel Ruiz-Gabarre and
  • Vega García-Escudero

26 January 2019

As life expectancy is growing, neurodegenerative disorders, such as Alzheimer’s disease, are increasing. This disease is characterised by the accumulation of intracellular neurofibrillary tangles formed by hyperphosphorylated tau protein, senil...

  • Feature Paper
  • Review
  • Open Access
29 Citations
7,230 Views
11 Pages

22 January 2019

Exercise plays an important role in brain plasticity, leading to improvements in cognitive function and delaying the cognitive deterioration of healthy people. These effects can be observed in individuals with schizophrenia through improvements in th...

  • Article
  • Open Access
11 Citations
4,723 Views
10 Pages

PAOT-Liquid® Technology: An Easy Electrochemical Method for Evaluating Antioxidant Capacity of Wines

  • Pincemail Joël,
  • Kaci Mouna-Messaouda,
  • Kevers Claire,
  • Tabart Jessica,
  • Ebabe Elle Raymond and
  • Meziane Smail

21 January 2019

Polyphenol compounds present in high quantity in wines are well-known to have potent cardio-protective properties through several biological mechanisms including antioxidant activity. A large number of methods have been developed for evaluating the a...

  • Review
  • Open Access
19 Citations
10,770 Views
7 Pages

17 January 2019

Few major advances in fighting parasitic diseases have been made in China since the development of new methods for prevention, control, and elimination. However, the proportion of immunocompromised individuals has increased due to the growth of chron...

  • Review
  • Open Access
29 Citations
8,748 Views
11 Pages

Potential Beneficial Effects of Wine Flavonoids on Allergic Diseases

  • Toshio Tanaka,
  • Atsuhiko Iuchi,
  • Hiroshi Harada and
  • Shoji Hashimoto

15 January 2019

Wine, a widely consumed beverage, comprises several biophenols that promote health. Flavonoids, majorly present in red wine, have been shown to have antioxidant, anti-inflammatory, anticancer, and immunomodulatory activities. Regular consumption of r...

  • Review
  • Open Access
14 Citations
5,853 Views
13 Pages

14 January 2019

Alloimmunisation to platelet antigens is not uncommon; a large number of females, having had pregnancies, developed antibodies to Human Leukocyte Antigen (HLA) moieties harboured on their foetuses’ cells (inherited from the father(s)) that may...

  • Feature Paper
  • Article
  • Open Access
57 Citations
9,316 Views
14 Pages

Prevalence, Wellbeing, and Symptoms of Dysmenorrhea among University Nursing Students in Greece

  • Eugenia Vlachou,
  • Dimitra Anna Owens,
  • Maria Lavdaniti,
  • John Kalemikerakis,
  • Eleni Evagelou,
  • Nikoletta Margari,
  • Georgia Fasoi,
  • Eftychia Evangelidou,
  • Ourania Govina and
  • Athanasios N. Tsartsalis

Dysmenorrhea (pain during menstruation) is one of the most common medical conditions among women of reproductive age. Dysmenorrhea has been studied around the world but not yet in Greece. The aim of the present study was to investigate the prevalence...

  • Article
  • Open Access
10 Citations
4,665 Views
10 Pages

Cystic echinococcosis (CE) is recognized as a neglected disease of public health significance throughout the world, particularly in low and middle-income countries. The objectives of this study were to describe the characteristics, attitudes, knowled...

  • Review
  • Open Access
8 Citations
18,771 Views
12 Pages

29 December 2018

Scabies is a significant public health condition in long-term care facilities, plaguing even developed countries. Although treatments are available, eradication and control of scabies cases still remain a challenge due to delays in diagnosis and diff...

  • Article
  • Open Access
20 Citations
4,475 Views
10 Pages

Plasma Levels of Cytokines (IL-10, IFN-γ and TNF-α) in Multidrug Resistant Tuberculosis and Drug Responsive Tuberculosis Patients in Ghana

  • Anthony Basingnaa,
  • Samuel Antwi-Baffour,
  • Dinah Obenewaa Nkansah,
  • Emmanuel Afutu and
  • Enid Owusu

23 December 2018

The emergence of multidrug-resistant tuberculosis (MDR–TB) and more recently, extensively drug-resistant (XDR) TB has intensified the need for studies aimed at identifying factors associated with TB drug resistance. This study determined the di...

  • Feature Paper
  • Article
  • Open Access
9 Citations
4,342 Views
17 Pages

20 December 2018

SET and MYND Domain 1 (SMYD1) is a cardiac and skeletal muscle-specific, histone methyl transferase that is critical for both embryonic and adult heart development and function in both mice and men. We report here that skeletal muscle-specific, myoge...

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Diseases - ISSN 2079-9721