Table of Contents
Diseases, Volume 7, Issue 1 (March 2019) – 32 articles
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Cover Story (view full-size image) Myogenin–Cre-mediated deletion of the SET and MYND Domain 1 (SMYD1) lysine methyl transferase in [...] Read more. Myogenin–Cre-mediated deletion of the
SET and MYND Domain 1 (SMYD1) lysine methyl transferase in skeletal muscle results in perinatal death in mice. Severe defects in pectoral (white arrows) and sternohyoid (yellow arrows) muscles, as well as accumulation of excessive brown adipose tissue (pink), were observed in the conditional knockout (CKO, right) relative to wild-type (WT, left). Dorsal muscles (blue arrows) were also significantly diminished, whereas other skeletal muscles were left unscathed. Shown are the in situ Myogenin hybridization sections at embryonic (E) stage (15.5 days). View this paper.