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Keeping an Eye on Perimenopausal and Postmenopausal Endometriosis

1
Department of Obstetrics & Gynecology, Venizeleio General Hospital of Heraklion, 71409 Crete, Greece
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3rd Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
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Section of Molecular Pathology and Human Genetics, Department of Internal Medicine, School of Medicine, University of Crete, 71003 Heraklion, Greece
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Histopathology Department, University General Hospital of Heraklion, Medical University of Crete, 71110 Heraklion, Greece
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Department of Obstetrics & Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA
*
Author to whom correspondence should be addressed.
Diseases 2019, 7(1), 29; https://doi.org/10.3390/diseases7010029
Received: 19 January 2019 / Revised: 1 March 2019 / Accepted: 9 March 2019 / Published: 12 March 2019
Introduction: We aimed to describe and review the epidemiological aspect of the disease pattern of a series of perimenopausal and postmenopausal women with a histology confirmation of endometriosis. Material and Methods: We retrospectively examined the clinical records of 184 perimenopausal and 46 postmenopausal women with endometriosis. Data were collected and analyzed from 1100 patients’ charts with confirmed endometriosis and involved cases from two different geographical areas, New Haven (US) and Greece. The statistical methods included ×2 and the Mann-Whitney U test. In the perimenopausal group (age 45–54 years), there were 184 patients (16.7%) and the postmenopausal group (55–80 years) had 46 (4.2%). The average age of diagnosis was (49 ± 2.3) and (61.2 ± 5.1), respectively (p < 0.01). Results: Advanced endometriosis was more aggressive in the perimenopausal group (p < 0.05); in the same group, we observed a higher left-sided predisposition of endometriosis in comparison with the right side (p < 0.01). Endometrioma was the most common gynecological condition among patients with perimenopausal endometriosis in relation to the postmenopausal group (p < 0.001). Additionally, we found uterine leiomyomata more prominent in the perimenopausal group (p < 0.05). In contrast, adenomyosis was found higher in postmenopausal patients (p < 0.05); further, 24 cases with dry eye we observed. Conclusions: Postmenopausal endometriosis is an important underestimated condition. Although the reported situation is not common, various clinicopathological characteristics were observed in both groups. Clinicians should be aware that there is a correlation between endometriosis and endometriosis-associated ovarian cancer in perimenopausal and postmenopausal age. View Full-Text
Keywords: endometriosis; perimenopause; postmenopause; dry eye endometriosis; perimenopause; postmenopause; dry eye
MDPI and ACS Style

Matalliotakis, M.; Matalliotaki, C.; Trivli, A.; Zervou, M.I.; Kalogiannidis, I.; Tzardi, M.; Matalliotakis, I.; Arici, A.; Goulielmos, G.N. Keeping an Eye on Perimenopausal and Postmenopausal Endometriosis. Diseases 2019, 7, 29.

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