Next Article in Journal
Special Issue: Wine and Vine Components and Health
Previous Article in Journal
Salmonella Infection in Chronic Inflammation and Gastrointestinal Cancer

Keeping an Eye on Perimenopausal and Postmenopausal Endometriosis

Department of Obstetrics & Gynecology, Venizeleio General Hospital of Heraklion, 71409 Crete, Greece
3rd Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Section of Molecular Pathology and Human Genetics, Department of Internal Medicine, School of Medicine, University of Crete, 71003 Heraklion, Greece
Histopathology Department, University General Hospital of Heraklion, Medical University of Crete, 71110 Heraklion, Greece
Department of Obstetrics & Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA
Author to whom correspondence should be addressed.
Diseases 2019, 7(1), 29;
Received: 19 January 2019 / Revised: 1 March 2019 / Accepted: 9 March 2019 / Published: 12 March 2019
Introduction: We aimed to describe and review the epidemiological aspect of the disease pattern of a series of perimenopausal and postmenopausal women with a histology confirmation of endometriosis. Material and Methods: We retrospectively examined the clinical records of 184 perimenopausal and 46 postmenopausal women with endometriosis. Data were collected and analyzed from 1100 patients’ charts with confirmed endometriosis and involved cases from two different geographical areas, New Haven (US) and Greece. The statistical methods included ×2 and the Mann-Whitney U test. In the perimenopausal group (age 45–54 years), there were 184 patients (16.7%) and the postmenopausal group (55–80 years) had 46 (4.2%). The average age of diagnosis was (49 ± 2.3) and (61.2 ± 5.1), respectively (p < 0.01). Results: Advanced endometriosis was more aggressive in the perimenopausal group (p < 0.05); in the same group, we observed a higher left-sided predisposition of endometriosis in comparison with the right side (p < 0.01). Endometrioma was the most common gynecological condition among patients with perimenopausal endometriosis in relation to the postmenopausal group (p < 0.001). Additionally, we found uterine leiomyomata more prominent in the perimenopausal group (p < 0.05). In contrast, adenomyosis was found higher in postmenopausal patients (p < 0.05); further, 24 cases with dry eye we observed. Conclusions: Postmenopausal endometriosis is an important underestimated condition. Although the reported situation is not common, various clinicopathological characteristics were observed in both groups. Clinicians should be aware that there is a correlation between endometriosis and endometriosis-associated ovarian cancer in perimenopausal and postmenopausal age. View Full-Text
Keywords: endometriosis; perimenopause; postmenopause; dry eye endometriosis; perimenopause; postmenopause; dry eye
MDPI and ACS Style

Matalliotakis, M.; Matalliotaki, C.; Trivli, A.; Zervou, M.I.; Kalogiannidis, I.; Tzardi, M.; Matalliotakis, I.; Arici, A.; Goulielmos, G.N. Keeping an Eye on Perimenopausal and Postmenopausal Endometriosis. Diseases 2019, 7, 29.

AMA Style

Matalliotakis M, Matalliotaki C, Trivli A, Zervou MI, Kalogiannidis I, Tzardi M, Matalliotakis I, Arici A, Goulielmos GN. Keeping an Eye on Perimenopausal and Postmenopausal Endometriosis. Diseases. 2019; 7(1):29.

Chicago/Turabian Style

Matalliotakis, Michail, Charoula Matalliotaki, Alexandra Trivli, Maria I. Zervou, Ioannis Kalogiannidis, Maria Tzardi, Ioannis Matalliotakis, Aydin Arici, and George N. Goulielmos. 2019. "Keeping an Eye on Perimenopausal and Postmenopausal Endometriosis" Diseases 7, no. 1: 29.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop