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Diseases, Volume 13, Issue 2

February 2025 - 38 articles

Cover Story: Atypical parkinsonian syndromes (APSs) are heterogenous neurodegenerative disorders that differ from idiopathic Parkinson's disease (iPD) in their clinical, genetic and pathological features. Multiple system atrophy (MSA), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are the most common APSs. They are clinically characterized by varying combinations of levodopa-poorly responsive parkinsonism (rigidity, bradykinesia, tremor, and postural instability) and motor, cerebellar and other signs. Among the wide spectrum of non-motor symptoms, prominent cognitive impairment includes global cognitive deficits, memory, executive, attentional, and visuospatial language and non-verbal dysfunctions. View this paper
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Articles (38)

  • Article
  • Open Access
1 Citations
3,716 Views
23 Pages

Effects of Accentuated Eccentric and Maximal Strength High-Resistance Training Programs with or Without a Curcumin-Based Formulation Supplement on Body Composition, Blood Pressure, and Metabolic Parameters in Older Adults

  • Alvaro Juesas,
  • Angel Saez-Berlanga,
  • Carlos Babiloni-Lopez,
  • Ezequiel G. Martin,
  • Luis Garrigues-Pelufo,
  • Ana Ferri-Caruana,
  • Javier Gene-Morales,
  • Fernando Martin-Rivera,
  • Iván Chulvi-Medrano and
  • Pablo Jiménez-Martínez
  • + 15 authors

18 February 2025

Background/Objectives: This study compared the effects of high-resistance training (RT) programs, with or without curcumin supplementation, on variables commonly associated with metabolic syndrome (MetS), including body composition, blood pressure, a...

  • Article
  • Open Access
6 Citations
2,511 Views
13 Pages

Orbital Radiotherapy for Graves’ Ophthalmopathy: Single Institutional Experience of Efficacy and Safety

  • Madalina La Rocca,
  • Barbara Francesca Leonardi,
  • Maria Chiara Lo Greco,
  • Giorgia Marano,
  • Roberto Milazzotto,
  • Rocco Luca Emanuele Liardo,
  • Grazia Acquaviva,
  • Viviana Anna La Monaca,
  • Vincenzo Salamone and
  • Antonio Basile
  • + 7 authors

17 February 2025

Graves’ ophthalmopathy is the most common extrathyroidal manifestation of Graves–Basedow disease. Radiotherapy is effective especially when used in synergy with the administration of glucocorticoids. The aim of our study was to analyze the effectiven...

  • Article
  • Open Access
4 Citations
2,148 Views
19 Pages

TREM2 Alleviates Neuroinflammation by Maintaining Cellular Metabolic Homeostasis and Mitophagy Activity During Early Inflammation

  • Lingfeng Hu,
  • Jie Liu,
  • Jie Peng,
  • Xiao Li,
  • Zhangqiong Huang,
  • Caixing Zhang and
  • Shengtao Fan

16 February 2025

Aims: Inflammation is a pivotal characteristic of neurodegenerative diseases. The triggering receptor expressed on the myeloid cells 2 (TREM2) gene has previously been shown to suppress inflammation by directly inhibiting inflammation-related pathway...

  • Review
  • Open Access
4 Citations
8,707 Views
26 Pages

Understanding the Burden and Management of Urinary Tract Infections in Women

  • Baiken Baimakhanova,
  • Amankeldi Sadanov,
  • Lyudmila Trenozhnikova,
  • Assya Balgimbaeva,
  • Gul Baimakhanova,
  • Saltanat Orasymbet,
  • Diana Tleubekova,
  • Alma Amangeldi,
  • Zere Turlybaeva and
  • Zhanar Nurgaliyeva
  • + 6 authors

15 February 2025

Urinary tract infections (UTIs) represent a prevalent health concern among the female population, with anatomical and physiological determinants such as a shorter urethra and its proximity to the rectum augmenting vulnerability. The presence of Esche...

  • Article
  • Open Access
1 Citations
1,678 Views
17 Pages

Knowledge and Predictors of Vitamin D Awareness Among Greek Women: A Cross-Sectional Study

  • Gavriela Voulgaridou,
  • Fani Athanassiou,
  • Eirini Kravvariti,
  • Stephania Doulgeraki,
  • Sousana K. Papadopoulou and
  • Lambros E. Kokokiris

15 February 2025

Background: Vitamin D plays a crucial role in bone health, calcium absorption, and immune function, yet significant misconceptions and knowledge gaps persist. This study aimed to assess knowledge regarding vitamin D among Greek women and identify fac...

  • Article
  • Open Access
3 Citations
1,353 Views
14 Pages

Evaluating the Association of Sociodemographic, Anthropometric, and Lifestyle Factors with Emotional Eating: A Cross-Sectional Study

  • Maria Mentzelou,
  • Sousana K. Papadopoulou,
  • Evmorfia Psara,
  • Theophanis Vorvolakos,
  • Constantina Jacovides,
  • Ioanna P. Chatziprodromidou,
  • Eleftherios Lechouritis,
  • Maria Mitsiou and
  • Constantinos Giaginis

14 February 2025

Background/Objectives: Emotional eating is an eating behavior that is influenced by behaviors, stress, emotions, and individual feelings in relation to eating. For many decades, studies have shown that mental health is the complex outcome of numerous...

  • Review
  • Open Access
5,247 Views
21 Pages

Nutritional Status of Adult People Living with HIV: A Narrative Review

  • Stella Proikaki,
  • Nikolaos Georgiadis,
  • Theodoros N. Sergentanis,
  • Eleni Kornarou and
  • Tonia Vassilakou

14 February 2025

Background: The interaction between HIV infection, nutrition and immune system functioning is intricate, leading, in many cases, to a cycle of poor health outcomes. Despite the widespread use of highly active antiretroviral therapy (HAART) since the...

  • Perspective
  • Open Access
10 Citations
17,317 Views
19 Pages

13 February 2025

Obesity has emerged as a global epidemic, creating an increased burden of weight-related diseases and straining healthcare systems worldwide. While the fundamental principle of energy balance—caloric intake versus expenditure—remains cent...

  • Review
  • Open Access
1 Citations
2,537 Views
34 Pages

An Analysis of Primary Hyperparathyroidism in Association with Depression or Anxiety

  • Ana-Maria Gheorghe,
  • Claudiu Nistor,
  • Aurelian-Emil Ranetti and
  • Mara Carsote

12 February 2025

Background: Non-classical manifestations such as neuropsychiatric manifestations in primary hyperparathyroidism (PHPT) have long been documented as symptoms of PHPT and are commonly reported by these patients, despite this connection still being a ma...

  • Review
  • Open Access
11 Citations
6,090 Views
20 Pages

Oxidative Stress in Benign Prostatic Hyperplasia: Mechanisms, Clinical Relevance and Therapeutic Perspectives

  • Aris Kaltsas,
  • Timoleon Giannakas,
  • Marios Stavropoulos,
  • Zisis Kratiras and
  • Michael Chrisofos

11 February 2025

Background/Objectives: Benign prostatic hyperplasia (BPH) is among the most common conditions affecting men as they age, resulting in lower urinary tract symptoms (LUTS) that can profoundly impact quality of life. While historically attributed primar...

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Diseases - ISSN 2079-9721